As the public’s interest in preventative healthcare and nutrition has grown, it has extended to their animal companions. In the The Complete Guide to Holistic Cat Care: An Illustrated Handbook, renowned author and nutritionist Celest Yarnall Ph.D. and esteemed holistic veterinarian, Jean Hofve, D.V.M., describe how to use Eng3′s Activated Air device for cats. Cats, like humans, benefit from improved cellular activities, most importantly the metabolism of oxygen and cell energy production.
People breath Activated Air through a nasal cannula, tubing with a fitting under the nose, which is not suitable for cats. The authors suggest that the best way to give Activated Air to cats is to cut the fitting off and put the tube (and the cat) in a carrier with a towel over it. The benefits make this extra attention worthwhile, as the authors state:
“Since many illnesses are the result of diminished oxygen utilization and oxidative stress damage such as excessive free radicals, inhaling air from the device improves the body’s use of oxygen, oxidative response, and defense against free radical damage. Ultimately, it promotes cell regeneration, protects against premature again and disease, boosts the immune system and provides sustainable energy for better overall health and vitality”
(The Complete Guide to Holistic Cat Care, Page 122.)
The Complete Guide to Holistic Cat Care: An Illustrated Handbook, provides a groundbreaking, revolutionary and alternative approach to feline healthcare. It is the first anti-aging book for companion cats. Groundbreaking anti-aging modalities like Eng3′s technology, have never before been published in a pet care guide. They provide innovative and successful approaches to providing cats with the healthiest and longest lives possible.
The Complete Guide to Holistic Cat Care is available now through www.celestialpets.com and www.amazon.com, where it is garnishing 5-star reviews.
Eng3′s Activated Air Device is described at www.eng3corp.com or you can learn more by calling the company directly at 877 571-9206.
Many people have found benefit to using Activated Air while they sleep. Activated Air devices with software version 1.2 or higher have a continuous operation setting, enabling the device to run all night long without having to restart a session. To see which software version you have – turn your device on – while it runs through the self test the software version number will display in the lower right corner. If it is 1.2 or higher, follow the directions below.
If you prefer to sleep while breathing from your activated air device, you may wish to purchase a mask designed for oxygen which may be more comfortable and stay on better than a nasal cannula. We like the “Adult elongated medium concentration oxygen mask” made by Salter Labs. One version has a standard elastic strap which goes around the head, another version has a strap which goes around the ears and under the chin. Note that if the mask does not come with tubing, you will need to also buy oxygen tubing. Standard length is 7 feet.
Please contact Eng3 for more specifics. Also, be sure to read our blog to set your device to continuous operation so you experience the benefits of activated air all night long.
Although it is known that the growth of cancerous tumors is impacted by the buildup of free radicals, treatments using anti-oxidants or pro-oxidants have had mixed results, according to a paper posted by the University of Michigan, because of the way patients differ in their oxidative stress levels.
“Being able to monitor a marker of oxidative stress that is associated with the activation of tumor cell growth pathways, particularly at an early stage, and then tailor treatments accordingly would allow for more targeted studies and might improve the odds of success with antioxidants and pro-oxidants,” says University of Michigan chemical biologist Kate Carroll.
Carroll and colleagues have developed a method to detect oxidative stress assessing “sulfenic acid in proteins – a tipoff to early oxidative stress and to a specific protein modification associated with cell growth pathways.” The sulfenic acid makes patterns which indicate varying levels of oxidative stress.
“Whether the patterns we see will correlate with response to antioxidant treatment or other therapies that modulate oxidative stress level remains to be seen, but now we at least have a way to investigate that question” says Carroll.
In the future, Carroll intends to determine which specific proteins play a role in the disease process, and she anticipates that many proteins are involved.
Eng3 is excited to be doing our part to help the planet. We have converted our packing materials for the Activated Air devices to use more recyclable materials and less foam. We’ve even reduced packaging from three boxes down to one. Ensuring our Activated Air devices arrive safe and sound is top priority, so it was no easy task to find a way to use less foam while still meeting our standards for shipping protection. But we found a way! The changes we’ve made mean there is less to go into the recycle bin, and minimal to toss into the garbage.
The mechanism of how oxidative stress causes damage and its underlying role in aging is documented in many studies. The medical implications of damage that leads to chronic disorders are increasingly being published and can be found when searching: oxidative stress “disease name” (ex: oxidative stress asthma).
In biophysics and cell-biology the process that involves proteins to protect against oxidative stress damage is known as oxidative response. The fact is that oxidative stress damages proteins and damaged proteins have a diminished repair capability.
This important repair mechanism for RNA and DNA is described in detail in the Journal of Biomedicine and Biotechnology: Oxidative Damage to RNA in Neurodegenerative Diseases
Nunomura et al. describe the importance of the repair mechanism for RNA. If the repair mechanism is diminished it can lead to neurodegenerative diseases including Alzheimer’s disease, Parkinson’s disease, Down syndrome, Dementia with Lewy Bodies, and Prion disease. In detail they explain the involvement of proteins in enzymatic reactions that are responsible for protection against oxidative stress and summarize it:
“Furthermore, cells have mechanism of dealing with nucleotide damage other than direct repair, which seems to be useful for defense against oxidative damage to both DNA and RNA.”
At ENG3 Corporation, our focus is to design devices that improve oxidative response. A biophysical treatment is available with Eng3’s technology, which is drug-free and extremely easy to use. Addressing protein structure is being implemented in medical clinics, medi-spas and wellness centers. Home users are also using it to address age-related disorders and as a breakthrough prevention tool.
Researchers at the University of Cambridge have determined the role of a protein called Nanog. It’s been known for several years that Nanog is a key player “in the system that keeps stem cells in a constant, undifferentiated ‘pluripotent’ form.”
But in a recent study, researchers found that “Nanog acts like a conductor in charge of an orchestra of genes and proteins during the final performance. All must play at the right time in perfect harmony for the cell to ‘refresh’ into a pluripotent state. Without Nanog, a stem cell cannot maintain an immortal pluripotent state….The protein must be present during the final reprogramming phase when other key factors are already present, otherwise the cell becomes ‘stuck’ in a halfway state of development.”
This is yet another example of the importance of protein function – if the Nanog protein is not functioning properly, stem cells do not develop correctly. All the more reason to support protein function. You may be interested to read Eng3′s Activated Air blog: Stem Cell Transplants and Oxidative Stress
Source: 2009, August 24. Discovery reveals more about stem cells’ immortality. Wellcome Trust. http://www.wellcome.ac.uk/News/2009/WTX056296.htm
Cellular activity is the entire orchestra of protein functions. While many protein functions are understood and recognized, the majority are not. The proteins involved in cellular activity are constantly being deciphered, explored and researched. Right now, the importance of the protein structure for protein function is well known, and innovative technologies are designed to improve the protein structure. With this growing knowledge we are able to address aging and health issues.
When cellular activity declines it means protein functions are not running as properly as they once did. Reduced cellular activity is more or less recognizable. On the mayo clinic website, examples of declining functions and their consequences are presented – see “Aging: What to expect as you get older” at http://www.mayoclinic.com/health/aging/HA00040
Most of today’s solutions for declining cellular activity are based on the approach to add more proteins to the body. These proteins could be hormones, enzymes, co-enzymes and even entire stem cells with thousands of different proteins in them. Other approaches attempt to reduce the causes leading to the decline in function, especially those that lead to damage of the protein structure. By far the most innovative approach is to improve the protein structure and consequently, cellular activity, through biophysical technologies. Improving the damage of protein structure results in the broadest improvement in cellular activity and is implemented by anti-aging and healthy-aging conscious users.
Eng3 Corporation is focused on improving cellular activity through a drug-free, biophysical approach. For more information please visit: www.eng3corp.com
The oxygen metabolism is the major process involved in cell energy production. There are two main aspects of the oxygen metabolism: Oxidative Stress and Oxidative Response.
This White Paper briefly describes each of these terms and suggests search phrases that can be used to find more information on each topic. This discussion is followed by a brief explanation of how Activated Air relies on these natural processes to help the body increase cell energy production.
Oxidative Stress:
Oxidative Stress describes cell damage caused by an overabundance of oxidants, including reactive oxygen species (ROS). The two types of ROS are free radicals and activated oxygen species. ROS are harmful in excess, but some levels of them are necessary for important cell functions. For example, singlet oxygen, which is an activated oxygen species, is involved in cell signaling that triggers the Oxidative Response System within the cells.
ROS and Oxidative Stress cause aging as well as many diseases and disorders, including:
Inflammatory skin diseases
Cardiovascular diseases
Autoimmune diseases
Neurodegenerative diseases
Mitochondrial diseases
Diabetes
Respiratory/Pulmonary diseases
Cancer
Chronic Fatigue Syndrome
Alzheimer’s disease
Huntington’s disease
Parkinson’s disease
Lou Gehrig’s disease
Ischemia
Hyperoxia
Macular degeneration
Other chronic diseases
To find additional related disorders please Google: Oxidative Stress and Oxidative Response together.
Oxidative Response:
The cellular defense against Oxidative Stress is the Oxidative Response. The Oxidative Response System (or cell response system) protects against, and repairs, Oxidative Stress damage. This is accomplished mainly through enzyme and coenzyme production. The Oxidative Response is initiated by signal transduction sequences induced by singlet oxygen. Singlet oxygen is an activated oxygen species, but not a free radical. Signaling proteins then trigger the cell response.
Cell response results include, but are not limited to:
Protection against free radical damage
Repair of damage caused by free radicals
Improved Oxygen utilization
Improved cell energy production
Improved cell metabolism
For optimal cell metabolism, a strong Oxidative Response and low Oxidative Stress are essential.
The Solution:
Activated Air technology has a patented process that generates an activated oxygen species, in this case singlet oxygen, in a contained activation chamber within the device. This unstable singlet oxygen quickly reverts back to triplet oxygen. Relaxation energy is emitted and quenched to water molecules in air flowing through the activation chamber. This is the same process that occurs continuously in the watery environment within the
cells. Those water molecules, inside and outside of the cells, are understood to be vehicles for the signal transduction sequences. After inhalation, and in contact with cells, the signal transduction initiates the cell response and the cellular defense mechanism.
Areas of use of Activated Air technology:
Prevention against any age-related disorders
Biological and physiological improvements, where optimal cell energy production is needed (cell regeneration, cell rejuvenation, recovery)
Physiological improvement for disorders caused by Oxidative Stress
Physiological conditions that cause Oxidative Stress
Hypertension Warning Signs
To find out more about a disorder that could be addressed with activated air, please contact www.eng3corp.com, (877) 571-9206 or email info@eng3corp.com.
According to the Baltimore Sun, there is no doubt that “silver is the new green for the fitness industry.” An increasing number of people are working, and working out, to prevent a decline in mental and physical health as they age. The Sun puts it this way: “As the Woodstock generation rocks into their 60s, they are revolutionizing yet another aspect of society, the gym. Looking to maintain a healthy quality of life, members more than 55-years-old joined gyms over the past 15 years at double the rate of the 35 to 54 age group. Fitness centers looking to capture this lucrative older market are springing up all over the country.”
Currently these silver-friendly gyms are offering a more peaceful and less competitive environment, low impact equipment for cardio workouts and classes (as well as personal trainers) suited to older bodies. Some leading gyms are offering technology for improving brain skills. This type of service responds to the growing urgency of people trying to avoid Alzheimer’s or other forms of dementia as they age.
Overall, we can expect to see more fitness centers catering to aging baby boomers and more of these centers offering health solutions that extend far beyond exercise. Eng3′s Activated Air is an ideal fit for these fitness centers.
Analysis of heart rate variability (HRV) – a powerful diagnostic tool HRV analysis is a straightforward, quick and non-invasive diagnostic procedure which is scientifically based and recognized. “If a superordinate system controls and regulates subordinate systems, the operational state of the superordinate system is the most important parameter for diagnosing disorders!”
What is significant and unique about HRV analysis is its ability to display quickly, in a completely painfree, non-invasive and meaningful manner, the autonomic nervous system’s (ANS) capacity to regulate. See document below for the full story, visit Eng3Corp.com or call 877.571.9206.
According to National Diabetes Information Clearinghouse (NDIC), Diabetes affects 23.6 million people-7.8 percent of the population- in the US. Like many other conditions, such as cardiovascular disease, the risk for developing type 2 diabetes increases with age and is most often diagnosed after the age of 45.
Many scientific disciplines, like biophysics and cell-biology, are involved in research and many publications about the disease are available and ongoing research will add. The knowledge about the mechanism of oxidative stress and diabetes is part of many biological researches. More in this article.
THE SOURCES AND THE TARGETS OF OXIDATIVE STRESS IN THE ETIOLOGY OF DIABETIC COMPLICATIONS Maria Mohora and her co-authors explain the relationship between oxidative stress and its medical implementation in form of diabetes. In short, oxidative stress is caused by an imbalance between the production of reactive oxygen, often called free radicals, and the oxidative response. The oxidative response in biological systems is able to readily detoxify the reactive intermediates or easily repair the resulting oxidative damage. It’s the cell’s protection shield against oxidative stress.
A biophysical approach, without drugs or other artificial substances, enables a new technology designed to improve oxidative response. Improving oxidative response is the focus of Eng3 Corporation and, with Eng3′s technology. Professionals in clinics as well as home users are addressing health problems caused by oxidative stress. This drug-free approach is available in Medical Clinics, Medispas and Wellness Centers that usually offer 20-minutes sessions. Home users can benefit from daily applications with their own device.
Learn more about oxidative stress treatment at Eng3Corp.com or call 877.571.9206.
One of the most exciting topics in medical research is protein modulation. This approach, which is clinically known as redox therapy or signal transduction therapy, holds great promise for a wide array of health issues. Because of the great potential in this area of cell science, Eng3 Corporation worked with Indiana University School of Medicine to summarize the current state of the scientific knowledge. The results describe the mechanisms that lead to oxidative stress damage and consider innovative technical solutions such as redox and signal transduction therapies.
Cellular activities are completely reliant on the interaction within and between protein structures. In recent years, scientists have come to realize that the failure of communication-molecular miscommunication-can be blamed for many health disorders. “Most of our diseases are related to intra- and intercellular communication disorders,” write the editors of Current Signal Transduction Therapy. “The concept of signal transduction therapy has gotten into the front line of modern research, and a multidisciplinary approach is being used to identify and treat signaling disorders.”[1]
One of the main culprits behind cellular miscommunication is oxidative stress damage, which is known to damage protein structures and therefore leads to a decline in cellular activity. Recent advances in biophysics are now being applied to state-of-the-art technology in protein modulation. These innovations aim to improve cellular activity, fight oxidative stress damage, and enhance the proper functioning of cells’ signaling pathways. Such technology therefore stimulates and strengthens the body’s oxidative response, which:
Preconditions the body’s defenses;
Correctly interprets the build-up of free radicals as a signal to act;
Counters oxidative stress and neutralizes (or scavenges) free radicals, by producing appropriate proteins and enzymes (antioxidants); and
Minimizes cellular DNA damage.
Prof. Dr. Gabi Nindl Waite, a leading research scientist in Cellular and Integrative Physiology at Indiana University School of Medicine, writes: “The potential of redox therapies to become an important part of conventional medicine is recognized by many.”[2] There is great optimism that redox therapies may dramatically improve health care outcomes. Conventional and naturopathic doctors, sports medicine professionals, and anti-aging specialists are already embracing progressive solutions like the device provided by Eng3 Corporation.
The impact of protein modulation technology on cellular activity
Clinical studies have shown improved cellular activity helps cells utilize oxygen better, improve their metabolism, fight oxidative stress damage, and enhance regeneration. Studies have shown quantifiable evidence of:
Increased heart rate variability (HRV) – the organism as a whole is healthier and all cellular processes are optimized;
Significant growth of reserves for cellular activity and increased energetic-metabolic efficacy – both subjectively noticeable and objectively measurable;
A decrease in organism stress – excessive stress-related damage is avoided;[3]
A lower percentage of unused oxygen is exhaled – the body is better able to utilize oxygen on the cellular level; and
A slower resting heart rate – cells perform faster and more efficiently.[4]
Of equal or perhaps greater significance is the fact that protein modulation technology will help people better manage age-related diseases and chronic disorders. People using these devices often report rapid and dramatic positive results, including:
Reduced inflammation;
Disappearance of pain and other symptoms related to chronic disorders;
Shortened recovery time and faster cell regeneration;
Improved sleep;
Increased energy, better concentration, faster reflexes, and greater mental awareness;
Improved vision and other age-related problems; and
A renewed sense of well-being.
Current state of protein modulation research
Researchers at Indiana University School of Medicine, in collaboration with Eng3 Corporation, summarized the current state of scientific knowledge regarding the mechanisms leading to oxidative stress damage. The results, which consider solutions such as redox and signal transduction therapy, were published in the Journal of Cell Science.[5] A short synopsis of the work suggests that reactive oxygen species (ROS) have been identified as being responsible for many harmful events in humans and, on the other hand, they are increasingly being recognized as necessary cell signaling agents. The multiple roles of ROS are reflected in the multiple roles of antioxidants, which are part of many disease preventing remedies, but are recently discussed as disease causing agents. The publication provides an overview of the current knowledge of ROS as part of complex redox networks that can harm or benefit cells. It presents up-to-date physicochemical and biological information, in an understandable, novel way, to involve the reader in the significant discussion on ROS and anti-ROS as the novel therapeutic agents of the coming decades.
Eng3 Technology: Proven approach for improving cellular activity
Eng3′s technology applies advances in biophysics for protein modulation, to improve cell activity and therefore strengthen cell metabolism, including the cellular oxidative response. This improves the body’s functionality, or more precisely its biomolecules-in the form of proteins and enzymes. By using the body’s own oxidative response capability, and the thousands of powerful enzymes at its disposal, this approach can slow and even reverse the damage associated with oxidative stress, disease, and aging.
A German consortium of some of the leading research institutions in the world made a formal study of this technology. After concluding its analysis, they wrote of the possibilities for such technology in the strongest terms: “In light of the key role of enzymes in biochemical processes, this technology cannot be overestimated with regard to its significance for microbiological processes and metabolic operations.” Conventional medicine, the Institute continued, could make use of this technology to help treat a wide range of conditions, including respiratory problems, arteriosclerosis, arthritis, chronic disorders, and degenerative diseases.[6]
After collaborating with Eng3 Corporation for more than six months, Dr. Waite reached a similarly enthusiastic conclusion: “It is a fascinating time for this field of research since it contributes to new therapies, which will lead into a new therapeutic era. Any therapy that specifically regulates the concentration, conformation, quaternary structure, or the location of proteins would be of great benefit for a wide range of medical conditions. Eng3, as I understand it, is developing such novel human therapies.” 2[7]
Prevention and restoration of physiological performance:
Patients can use Eng3′s patented, FDA-cleared device in integrated medical centers, advanced health clinics, centers for chronic disorders, sports centers, medispas, at the doctor’s office, and at home. Eng3 has both professional and home devices available. This therapy that can be used alone or with other treatments. For more information about Eng3′s Activated Air Technology, please contact Eng3 Corporation at 877.571.9206 or info@eng3corp.com.
[2] Dr. Gabi Nindl Waite, “Hydrogen Peroxide – From Oxidative Stressor to Redox Regulator,” Cellscience Reviews, Vol. 1, No. 2 (2004).
[3] Dr. Michael Kucera, “‘Active Air’ Inhalation Therapy: Autonomic Regulation Mechanisms with Use of Heart Rate Variability Analysis,” Explore! Volume 16, Number 2, 2007.
[4] Dr. Claudia Schöllmann, “Concentrated Oxygen and Activated Respiratory Air: A Comparison Between the Physiological Effects of Two Inhalation Applications,” Germany. Explore! Volume 15, Number 2, 2006.
[5] From Redox Homeostasis to Protein Structure Modulation and Redox Signaling Therapy
Gabi N. Waite and Walter X. Balcavage, Indiana University School of Medicine, Journal of Cell Science 2009, available at www.cellscience.com/Reviews19/Redox_signaling.html or directly from Eng3 Corporation.
[6] Delta-Ge, a research consortium that included, Germany’s prestigious Fraunhofer Institute ISE
[7] Dr. Gabi Nindl Waite, Department of Cellular and Integrative Physiology, University School of Medicine, Terre Haute, IN 47809
Proteins play a key role in biological processes. The proper function of proteins is important for cellular activity.
The understanding of protein structure and function in the context with human diseases and disorders is a common topic in Performance and Health Science, Medicine and Nursing, as well as Wellness and Healthy Aging.
In biological sciences, countless publications report about the various levels of protein structures, the complexity of the protein functions, and introduce modern techniques that are used in the analysis of structure and function. They also explore the rapidly developing area of protein-related biotechnologies and drug design. Other reports give examples of aberrations in protein structure that lead to alteration in function in a variety of biological contexts, emphasizing disease. The science around protein structure and function is one of the forefronts of the 21st century. The progress made in the last 50 years is immense.
At Eng3 Corporation we are focused on a biophysical approach for a non-chemical (drug-free) treatment. Our approach addresses a fundamental component of the structure for almost all proteins and therefore cannot be overestimated in regard to its significance. The focus on protein structure and how to protect and repair damage on it will effectively lead to protect and repair the protein function hence protect and repair the broad cellular activity and finally reflect on the entire organism, which is interpreted as prevention and restoration.
Eng3’s Technology in one of the leading ways to raise immune system and enable professionals to address symptoms often recognized as performance reduction, age-related health issues and chronic disorders. Because of the involvement of protein structure and function in many cellular processes like oxygen metabolism, the performance and health issues related to oxidative stress are targets for treatments with our technology.
Activated Air is a proven technology used by professional and individuals who want to enhance athletic performance, promote healthy aging or restore health. Eng3’s approach is to trigger the body’s natural response to oxidative stress and improve cellular activities like cell metabolism and the uptake of oxygen. Your body’s cells through the course of your life go through disease, aging and stress. Learn more about Motality with pulmonary hypertension and treatment for diseases of the respiratory system with Eng3.
The conversion of O2 gets weaker and weaker as we age deviating you from your optimum level…organs and cells do not get the optimum amount of energy and our metabolic system slows down. As an adult there is an aggressive increase in free radicals and the aging process is accelerated.
Improved cellular activity leads to better cell metabolism including cell energy production. It; enables peak mental and physical, performance, supports the immune system and prevents diseases and promotes healthy aging.
Activated Air helps to increase your body’s ability to absorb oxygen for a more efficient oxygen metabolism. Your body’s energy budget is improved, metabolism is stimulated and the bodies self-healing and regeneration powers are accelerated. Rejuvenated and revitalized cells are the best foundation for protecting and fighting against age-related health problems and disorders caused by inefficient energy production.
The benefits of improved cell performance are confirmed with test results. Heart Rate Variability, which is a measure of your underlying health is an easy way for doctors or individuals to measure improvement. Numerous more specific tests can be used to show results. Some of these tests are identified here at http://www.eng3corp.com
Lyme Disease is very complex and many approaches are used to address it. The July issue of the Townsend Letter has a number of insightful articles on Lyme Disease. In her article “Naturopathic Approaches to Lyme Disease Treatment”, Dr. McFadzean, provides a helpful overview of the different areas to address. These include:
Antimicrobials which is a complex subject that touches on the importance of breaking down the biofilm which is a hiding place for bacteria and viruses
Nutrition and Lifestyle factors including anti-inflammatory foods and avoiding certain foods, especially sugar because it is related to yeast overgrowth and compromises a healthy immune system
Detoxification which, although critically important, is a process that is often difficult for Lyme Disease patients to tolerate. Heavy metal toxicity causes neurological symptoms, fatigue and many other problems. Mold is a major source of neurotoxins that are common in people with Lyme
Immune support, immune system boosting techniques are critical in helping the body fight infections. Various ways to boost the immune system become even more important as Lyme progresses
Systemic inflammation, which is responsible for many of the symptoms of Lyme must be addressed. It can ultimately lead to problems with mood, anxiety and depression
Digestive issues are common and can be caused by opportunistic infections and parasites. Most Lyme patients avoid gluten and dairy products because they can fuel inflammation
Hormone imbalance is associated with Lyme and other chronic diseases
Imbalance in brain chemistry should be considered because Lyme disease can disrupt normal neurotransmitter pathways and depression and anxiety are common in these patients.
The list above is a brief overview of issues. More detail can be found in a highly regarded set of guidelines for diagnosing and treating Lyme that was developed by Dr. Joseph J. Burrascano and are available through the Lyme Disease Associationa as a pdf.
Also in the July issue of the Townsend Letter is an article by Scott Forsgren who has been addressing Lyme for more than 12 years. His article entitled “Microbes, Toxins and Unresolved Conflicts: a Unifying Theory” is especially meaningful coming from the perspective of a Lyme patient. What makes Scott exceptional is his dedication learning about Lyme disease and sharing what he has learned with others. He has developed a remarkable site at www.betterhealthguy.com
Information about how Eng3′s Activated Air device and immune system boosting techniques is used to help protect and repair the body at the cellular level can be found at the Need for Activated Air or by calling 877-571-9206.
Department of Clinical and Biomedical Sciences, Barwon Health, University of Melbourne, Geelong, VIC, Australia. felicitn@barwonhealth.org.au
Oxidative stress has been implicated in the pathogenesis of diverse disease states, and may be a common pathogenic mechanism underlying many major psychiatric disorders, as the brain has comparatively greater vulnerability to oxidative damage. This review aims to examine the current evidence for the role of oxidative stress in psychiatric disorders, and its academic and clinical implications.
Oxidative stress is caused by an imbalance between the production of reactive oxygen and a biological system’s ability to readily detoxify the reactive intermediates or easily repair the resulting damage. All forms of life maintain a reducing environment within their cells. This reducing environment is preserved by enzymes that maintain the reduced state through a constant input of metabolic energy. Disturbances in this normal redox state can cause toxic effects through the production of peroxides and free radicals that damage all components of the cell, including proteins, lipids, and DNA.
A literature search was conducted using the Medline, Pubmed, PsycINFO, CINAHL PLUS, BIOSIS Preview, and Cochrane databases, with a time-frame extending to September 2007. The broadest data for oxidative stress mechanisms have been derived from studies conducted in schizophrenia, where evidence is available from different areas of oxidative research, including oxidative marker assays, psychopharmacology studies, and clinical trials of antioxidants. For bipolar disorder and depression, a solid foundation for oxidative stress hypotheses has been provided by biochemical, genetic, pharmacological, preclinical therapeutic studies and one clinical trial. Oxidative pathophysiology in anxiety disorders is strongly supported by animal models, and also by human biochemical data. Pilot studies have suggested efficacy of N-acetylcysteine in cocaine dependence, while early evidence is accumulating for oxidative mechanisms in autism and attention deficit hyperactivity disorder. In conclusion, multi-dimensional data support the role of oxidative stress in diverse psychiatric disorders. These data not only suggest that oxidative mechanisms may form unifying common pathogenic pathways in psychiatric disorders, but also introduce new targets for the development of therapeutic interventions.
PMID: 18205981 [PubMed - indexed for MEDLINE]
Click here to learn more about oxidative stress and the risk and preventive factors for mental health disorders,
The U.S. Centers for Disease Control and Prevention’s outlook for 2009 highlights the reasons for concern about health care in America. In the document: Healthy Aging: Improving and Extending Quality of Life Among Oder Americans, the CDC notes the implications of the aging population. It is clearly more important than ever for people to take any measures they can to promote healthy aging. The excerpt below on healthy aging paints a telling picture.
At A Glance 2009
The Health and Economic Effects of an Aging Society
By 2030, the number of U.S. adults aged 65 years or older will more than double to about 71 million. The rapidly increasing number and diversity of older Americans has far-reaching implications for the U.S. public health system and will place unprecedented demands on aging services and the nation’s entire health care system.
For example, Medicare spending has grown about nine-fold in the past 25 years, increasing from $37 billion in 1980 to $336 billion in 2005. If left unchecked, health care spending will increase 25% by 2030, largely because of the aging population.
Chronic diseases disproportionately affect older adults and are associated with disability, diminished quality of life, and increased costs for health care and long-term care. Today, about 80% of older adults have at least one chronic condition, and 50% have at least two. These conditions can cause years of pain and loss of function. Public health efforts can help Americans avoid preventable illness and disability as they age. Research has shown that poor health is not an inevitable consequence of aging. Effective public health strategies currently exist to help older adults remain independent longer, improve their quality of life, and potentially delay the need for long-term care.
Source: Centers for Disease Control and Prevention, http://cdc.gov/
It is now generally agreed that oxidative stress plays a major role in disease. At every point in the day, cells are busily churning away to optimally promote health and fight attacks that can cause disease. Scientists don’t yet fully understand how all those complex functions operate; but they are getting there.
For a stock-taking of some of the new research relating to oxidative stress, here’s a generally readable but still scientifically detailed article: Oxidative activation of antioxidant defense.
It serves as a good primer for understanding the purpose of the approach that Eng3 Corporation is taking.
In the article, British and German scientists explain how disturbances occur in what is called “redox equilibrium.” That term refers to the balance in living cells between oxidizing and anti-oxidizing, or “reducing,” elements. Imbalance leads to an increase in concentrations of “reactive oxidizing species” which then take part in complex processes that can result in cell damage.
And that contributes to the development of many diseases, including rheumatoid arthritis, diabetes, cancer, Alzheimer’s disease, and many others.
The scientists, Paul G. Winyard, Christopher J. Moody, and Claus Jacob, note that the discovery of the extent of the association between redox disequilibrium and disease has prompted much research. They and their colleagues wish to know, for example, how living cells monitor, control, and maintain their own “redox balance” – how they respond to attacks on their redox balance.
Cells have both response and defense processes that protect against attack. The article explains that many of those processes rely on sulfar redox chemistry, while others are based on amino acid side chains in proteins that oxidative stress activates. Much remains to be learned about these responses, and descriptions of many of them are not easy for non-specialists to read. The article details, for example, cysteine-based redox regulation of the glutathione and thioredoxin pathways.
You may want to take it on faith that complex cell functions such as those exist, and that their proper functioning is crucial if you are to stay healthy.
Emory University and the Woodruff Health Sciences Center announced, “A team of scientists..[have] identified a direct link between oxidative stress and inflammatory signals in the blood.” In this study the team looked at the presence and effect of cysteine, an amino acid found in the body that is also a biomarker for oxidative stress. Higher levels of oxidative stress outside the cell are related to more oxidized cysteine.
The scientists found that inflammatory messages are sent by white blood cells when there is a high level of oxidized cysteine in the blood. Both oxidative stress and inflammation have been “linked to multiple age-related and chronic diseases,” notes Jones, a co-author. They go on to note the findings could help to lead to methods to prevent disease or reduce the impact of inflammation in critically ill patients.
Reference:
Iyer, S., et al. 2009. Cysteine Redox Potential Determines Pro-Inflammatory IL-1ß Levels. PLoS ONE 4(3): e5017.
Numerous people using Eng3′s device have also been treated with stem cell transplants. The Activated Air device can be very beneficial to people undergoing stem cell transplants because it promotes cellular activities. The importance of cellular activity for stem cell transplants starts early. Before stem cells are transplanted, they must possess sufficient biological activity to ensure that they will be successful once implanted. This is why scientists need to be certain that the stem cells are healthy and functioning before going through the process of transplantation. After transplantation the stem cells are exposed to the same protein-damaging effects as the entire organism. They are especially susceptible to oxidative stress damage. Protecting against this damage is critical. With support from Activated Air, critical protein functions such as oxidative response, are improved and oxidative damages are counterbalanced. Increasing the organism’s cellular activity is an excellent way to ensure health improvement for a client receiving stem cells.
The impact of oxidative stress on stem cells is multifold and described in depth in the scientific literature. Most research is specific to a particular protein function or dysfunction. However, the sum of proteomic stem cell research clearly points to the importance of protein function in beneficial stem cell activity. An excellent overview of this research is found in the article “Concise Review: Trends in Stem Cell Proteomics” Stem Cells Vol. 25 No. 8 August 2007, pp. 1888 -1903.
Next week is the national awareness day for Fibromyalgia and Chronic Fatigue. Eng3 Corporation has a keen interest in Fibromyalgia and CFS, and the research that is being done to find the cause(s). It seems a great deal of research indicates a correlation with mitochondria function as well as oxidative stress, as covered in the posts below.
In 2008 the American Journal of Biochemistry and Biotechnology released a special issue on Autism Spectrum Disorders (Vol 4, No. 2). Many studies in the issue provided evidence to support the concept of oxidative stress in autism. In fact, three separate studies showed increased oxidative damage in brain tissues from autistic subjects. Several articles looked at metal toxicity, including how lead and mercury can induce oxidative stress. A review of two articles also focused on the concept of mitochondrial dysfunction and how this can increase oxidative stress in autism.
The editor, Abha Chauhan writes, “Increased oxidative stress in autism may lead to membrane lipid abnormalities, altered cellular signal transduction, mitochondiral dysfunction, abnormal energy metabolism, excitotoxicity, inflammation and immune dysregulation in autism. These abnormalities may then contribute to abnormal brain development and function resulting in a spectrum of clinical manifestations in autism.”
Research in the field of Autism highlights the complexity of the disease and its treatment. Taking action to reduce oxidative should be a priority because oxidative stress plays a key role in Autism and a myriad of other illnesses. Learn more about this on the Need page.
May is Asthma Awareness Month. According to the National Heart Lung and Blood Institute, more than 16 million adults and 6 million children in the US are known to have asthma, a chronic lung disease characterized by inflamed and narrowed airways. Many people with asthma suffer with periods of wheezing, shortness of breath, coughing, and chest tightness. Severe asthma attacks may require emergency treatment and can cause death. In fact, it is estimated that there are 5,000 deaths per year related to asthma.
Currently, most options for asthma sufferers involve avoiding triggers in the environment, and quick acting and/or long term medications. Interestingly, an article by K. Ramanujan published at Cornell University (2006) reviewed research conducted at Cornell and Stanford which estimated that 4,000 out of the 5,000 deaths per year related to asthma are actually caused by a specific type of long acting asthma medication. There is obviously a great need for alternatives to asthma medication.
Danish scientists have shown that particulate air pollution increases oxidative stress-induced DNA damage. Their investigation concludes that “Oxidative stress-induced DNA damage appears to an important mechanism of action of urban particulate air pollution.” The authors also state that “Exposure to ambient air particulate matter (PM) is associated with pulmonary and cardiovascular diseases and cancer.”*
Common sense tells us that air pollution is not good for us. However, these authors identify a number of ways that reactive oxygen species can be generated by particulate air pollution, which leads to oxidative stress damage. The Danish team found overwhelming evidence, based on three different types of experiments, that exposure to diesel exhaust and diesel exhaust particles causes oxidative DNA damage.
Unfortunately much of the world’s population already lives in a polluted environment and we are seeing the results show up in the rise of oxidative stress-related diseases. A previous post discusses the remarkable increase in chronic diseases. Read more about oxidative stress- related diseases at Eng3′s Need page.
*Oxidative stress-induced DNA damage by particulate air pollution.
Risom L, Møller P, Loft S. Institute of Public Health, University of Copenhagen, Øster Farimagsgade 5, 1014 Copenhagen K, Denmark.
Sleep Apnea (or Sleep Apnoea), a condition where people stop breathing for periods of 10 seconds or longer while sleeping, affects up to 18 million people in the US. Interference in breathing reduces the amount of oxygen in the blood. Eventually this lack of oxygen triggers the lungs to suck in air, causing gasping or snorting, and for the person to move to a lighter stage of sleep, or sometimes to wake up.
Sleep apnea is associated with serious heart and circulatory problems including hypertension (high blood pressure) and heart disease, as well as asthma, diabetes, kidney failure, peripheral nerve damage, seizures, epilepsy, and other nerve disorders.
Adults suffering from sleep apnea may experience excessive daytime sleepiness, headaches, irritability, reduced concentration and impaired mental/emotional functioning. Essentially they are not getting deep, restful sleep and enough oxygen at night, which has significant effect on mental and emotional wellbeing, and health.
People who suffer from sleep apnea use Eng3′s device for several reasons:
1) At the cellular level, Eng3 technology is improving cell metabolism so cells utilize oxygen better. When using Eng3 technology, those who suffer from sleep apnea will be using oxygen better both while awake and while sleeping.
2) Improved cell metabolism and oxygen utilization contributes to improved concentration during the day and better sleep at night.
You may be interested in a study on Sleep Apnea done with our technology by Marion Burmann-Urbanek, M.D., and Hendrik Straube, M.D. Learn more about the physical symptoms of anxiety and stress and sleep apnea treatment with Activated Air.
For a session with Activated Air, you breathe air directly from the Activated Air device through a nasal cannula or diffuser. It does not fill the room like a humidifier or air purifier, but rather the Activated Air needs to reach you quickly and be breathed in. The cannula or diffuser attaches to the front of the device. With the cannula, the air is directed to your nose; with the diffuser the air is dispersed just in front of your mouth and nose.
For the professional device, the minimum session time is 20 minutes. For the home device the minimum time is 40 minutes. You can breathe normally during the session; some people do like to take deep breaths as well. You can do anything during your Activated Air session, as long as you can stay connected to the device. Many people sit and read, talk on the phone, or work on their computer. Some people sleep, and others use it while exercising, running on a treadmill, or doing yoga. It is also used in spas and wellness centers while people undergo other services such as massage, colon hydrotherapy, manicures and pedicures, etc.
It is recommended that you use Activated Air at least 3 times a week. Many people feel so good after using the device they choose to use it every day, and may do longer sessions as well.
According to the American Diabetes Association, 23.6 million children and adults have diabetes in the US. Dr. Martin Silink, the president-elect of the International Diabetes Federation, says ”diabetes is one of the biggest health catastrophes the world has ever seen.” The rate at which the incidence of diabetes is growing is what is causing so much concern. Globally, it has increased from 30 million to 230 million during the last 20 years, according to the International Diabetes Federation. Domestically, the diabetes epidemic is growing by almost 5% a year, according to a study led by Linda S. Geiss, of the Center for Disease Control. “We found that diabetes and obesity are growing together,” Geiss stated, “It has grown for the last 15 years and there is no hint of it slowing down.”
There are several studies which suggest that Oxidative Stress is related to diabetes. Motz and Ceriello (2004) published a paper in the Journal of the American Heart Association called Is Oxidative Stress the Pathogenic Mechanism Underliying Insulin Resistance, Diabetes, and Cardiovascular Disease? The Common Soil Hypothesis Revisited, reviewing the data and studies regarding the topic. They concluded “a puzzle of many pieces of evidence suggests that free radical overgeneration may be considered the key in the generation of insulin resistance, diabetes, and cardiovascular disease.” An additional concern is that recent research suggests that Diabetes may increase the risk of Alzheimers as reported last week by Lauran Neergaard of the Associated Press. Given that oxidaticve stress damage appears to be a factor in both diseases, this is not surprizing. See Alzheimers Related to Oxidative Stress.
Hans Eng, founder and CEO or Eng3 Corporation, will be speaking to the Arizona Homeopathic and Integrative Medical Association (AHIMA) on Wednesday April 1st in Phoenix Arizona. His presentation entitled The Role of Oxidative Stress in Cellular Activity and Protein Structure Modulation: A state-of-the-art approach for Performance and Health draws on his research which focuses on how to biophysically influence cellular activity, without the use of chemicals or pharmaceuticals. State-of-the-art technology works with the fundamental components that enable cellular activity, including microbiological processes and metabolic operations. Eng3’s technology is implemented where prevention and restoration of the cellular activity is the focus, either for protection, repair or improvement of the entire orchestra of cellular activity or for a particular segment of cellular activities. Eng3’s latest research initiative was done with the University of Indiana, School of Medicine. The resulting publication is available at www.cellscience.com/Reviews19/Redox_signaling.html
Hans Eng
About Hans Eng
Hans-Joachim Eng, Founder and CEO of Eng3 Corporation (www.eng3corp.com)
He holds an advanced degree in Mechanical Engineering and Material Science from the Technical University of Berlin. Before founding Eng3 Corporation, Hans owned and ran a German-based company that designed and produced human implants with a focus on the biophysical optimization to bone and tissue cells. He also managed quality assurance and production for the human implant division at Johnson & Johnson Corporation, and before that at Mecron GmbH.
Meeting details:
AHIMA Meeting
Wednesday April 1st 7:00 pm to 8:30 pm
Moon Valley Country Club
151 West Moon Valley Drive
Phoenix, AZ 85023 Contact Eng3 Corporation at 877.571.9206 for more information
March 21 , 2009 is World Down Syndrome Day and brings our attention to related conditions common in people with Down Syndrome (DS).
Although the cause of Down Syndrome has long been known to be a chromosomal disorder, interesting research is looking at conditions that occur in individuals with Down Syndrome. Such conditions include the development of Alzheimer like symptoms in their 30′s and 40′s, as well as the fact the “the incidence of autoimmune diseases and cataracts is significantly increased, and the overall ageing process is accelerated.” (Jonavic et al, 1998).
The authors suggest that these conditions are related to high levels of oxidative stress in Down Syndrom patients. After studying 166 subjects they concluded that their “results provide direct evidence for increased oxidative stress in individuals with DS.”
Eng3′s Activated Air device is designed to help cells repair and protect against damage caused by oxidative stress. By supporting the immune system and the body’s natural response to oxidative stress, Eng3′s Activated Air may be a good fit for people with DS.
Biomarkers of oxidative stress are significantly elevated in Down syndrome. Jovanovic S.V., Clements D., MacLeod K., Free Radic Biol Med. 1998 Dec;25(9):1044-8.
During 2008, Eng3 collaborated with the University of Indiana, School of Medicine to create a comprehensive overview of the state of scientific research in protein modulation. This research project produced excellent results including the articulation of connections between different areas of related science. The reference and introduction to the resulting publication is below.
From redox homeostasis to protein structure modulation and redox signaling therapy
Gabi N. Waite, Dept. of Cellular & Integrative Physiology & Walter X. Balcavage, Dept. of Biochemistry & Molecular Biology , Indiana University School of Medicine, Terre Haute, IN 47809, USA.
Reactive oxygen species (ROS) have been identified as being responsible for many harmful events in humans, while on the other hand, they are increasingly being recognized as necessary cell signaling agents. The multiple roles of ROS are reflected in the multiple roles of antioxidants, which are part of many disease preventing remedies, but are recently also discussed as disease causing agents. This article provides an overview of the current knowledge of ROS as part of complex redox networks that can harm or benefit cells. It presents up-to-date physicochemical and biological information, in an understandable, novel way, to involve the reader in the significant discussion on ROS and anti-ROS as the novel therapeutic agents of the coming decades.
The Centers for Medicare and Medicaid Services, known as CMS, released a report on the state of the US health care system. The current state of health care and, even more importantly the forecasts, make it abundantly clear that individuals should do everything possible to maintain good health. Some of the more interesting data from the CMS report are summarized below.
The share of the economy devoted to health spending will increase by a percentage point from 2008. This would represent the biggest one-year increase ever recorded – tracking began in 1960
Overall U.S. health spending in 2009 will hit $2.5 trillion, continuing a trend in recent decades that has seen healthcare encompass an ever-larger proportion of the economy.
It is projected that the health share of the economy will increase steadily through 2018. By 2018 health spending will be $4.4 trillion and make up 20.3 percent of the overall economy (it is currently $2.5 trillion and consumes 17.6 percent of the economy)
Spending for private health insurance is slowing as more people lose employer-provided coverage. However private health spending growth is expected to jump from 4.2 percent in 2010 to 6.1 percent by 2018
Growth in public health spending this year is projected to hit 7.4 percent, amounting to $1.2 trillion. This is largely because Medicaid assistance for the poor is ballooning. Public health spending will surge as the baby boom generation begins entering the Medicare health insurance program for people over 65
The CMS forecast reflect the stark reality of the US health system. Eng3 is doing everything we can to help people avoid the need to rely on it. Healthy aging is certainly the most cost effective way to go. Fortunately a growing number of people are investing in their health and taking preventative measures.
Dr Hekimi and colleague Jeremy Van Raamsdonk of McGill University studied mutant worms after they had progressively disabled five genes responsible for detoxifying ROS. Their results call into question the theory that oxidative stress causes aging. They found that reducing mitochondrial activity by damaging it with ROS did not reduce the life span of worms, and in one case made the worms live longer. While the authors refer to aging, it appears they studied longevity. The authors do not appear to have answered questions about the worms’ health and performance after they were damaged. This is perhaps the most important component of aging. It would be interesting to know if these damaged worms remained healthy or just lived as long (or longer) than their undamaged counterparts.
Since the mitochondria (the powerhouse of the cell) was damaged in the McGill study, the worms may have been alive but not as healthy as they otherwise would have been. Hopefully further study will investigate this and the possibility that damaging mitochondrial function resulted in lower oxygen metabolism and, as a result, actually decreased the kind of damage that would shorten the worm’s life. You may also be interested in Oxygen Ironey* and Healthy Aging and Anti Aging
Health and vitality during later stages of life is a primary reason for people to use Eng3’s Activated Air. Our focus is on the quality of life – helping people stay active, alert and vital as they age.
The second week in March is Multiple Sclerosis Awareness Week.
According to the National Institute of Health (NIH), it is estimated that between 250,000 and 350,000 people in the US have been diagnosed with MS, with 200 new cases diagnosed each week. This chronic disease is usually diagnosed in young adults (age 20-40), and those with MS have essentially the same life expectancy as those without MS. Due to the debilitating nature of the disease, “the economic, social, and medical costs associated with the disease are significant” (NIH), costing the US billions of dollars each year.
The cause is still unknown but many believe MS is an autoimmune disease, where the body’s own immune system is attacking the myelin around the nerves. Environment, genetics, viruses are all on the table as possible factors or triggers.
Calabrese et al, note “there is significant evidence that the pathogenesis of…multiple sclerosis… may involve the generation of reactive oxygen species (ROS),” and that there is evidence of mitochondria damage in these neurodegenerative disorders.
It may help to explain this with a bit more information. ROS are byproducts of oxygen metabolism and are highly reactive molecules. (Many people are familiar with the term free radicals – which are a type of ROS.) ROS can cause significant cell damage, also called oxidative stress damage. Mitochondria are damaged by ROS and are then unable to perform their functions, including making energy (ATP) for the cells. When the mitochondria become less effective at producing energy, cells may not function properly. [For more specifics on the role of mitochondria, see this blog.]. Eng3′s Activated Air device is specifically designed to improves cell function – it supports the mitochondria to optimize cell energy production and repairs damage caused by oxidative stress.Calabrese, V., et al., 2005, June 15. Oxidative stress, mitochondrial dysfunction and cellular stress response in Friedreich’s ataxia. The Journal of the Neurological Sciences, 233(1), 145-162.
Eng3′s Activated Air devices are not Oxygen Concentrators and they work in very different ways.
Oxygen concentrators increase the percentage of oxygen that you breathe – up to 100%. But breathing in more oxygen does not necessarily mean your cells can use it.
Eng3′s device modifies the air, so that your cells are able to use the oxygen better; but is not changing the amount of oxygen in the air – you still breathe the natural level of oxygen, about 21%. This improved oxygen utilization can be measured by the energy production of the cells and the amount of oxygen that is exhaled unused. Energy goes up and exhaled oxygen goes down.
The reason this is such an important difference is that the metabolism of oxygen by the cells naturally produces free radicals. This is natural and fine, unless there is an accumulation of free radical damage, which is called oxidative stress. Oxidative stress is associated with all chronic disorders and most diseases. When you breathe concentrated oxygen your cells must metabolize more oxygen, creating excessive free radicals and oxidative stress. Since Eng3’s device does not add more oxygen to your body, it does not create oxidative stress. In fact, our device helps reduce and repair oxidative stress damage by actually improving how your cells function.
For more information on how oxygen is essential, yet harmful – please read Eng3′s blogs:
“Oxygen is a relatively small element—number eight on the Periodic Table, for those who remember their high school chemistry. It is also highly reactive and electrically charged. Electrically charged atoms strive to become neutral, to have a particular number of electrons in their outer shells. Each atom of oxygen, with six electrons, needs two more to be complete. That is why it will eagerly combine with any electron-donating atom—hydrogen, for instance—whenever it is given the opportunity.
In the human body, of course, it is given that opportunity on a breath-by-breath basis. Each time a cells burns its oxygen fuel to create energy, it also creates freewheeling oxygen atoms known as oxygen free radicals.
Therein lies the problem. Oxygen is not discriminating about what other molecular structures it might destroy in its quest to become electrically whole. If there are electrons to spare in a protein molecule, or in the fats that make up a cells’ membrane, or even in the DNA that is crucial to the functioning of our cells and our bodies, it will grab them and change them. This constant cellular wear-and-tear due to the ravages of oxygen is so pervasive that it has been given a name: oxidative stress. And like its psychologically based cousin, oxidative stress can wear down a body over time.
Indeed, the biological consequences of this sort of electron scavenging can be found at the root of the normal process of aging. But it also has a part in cancer. Heart disease. Parkinson’s disease. Name the condition, and somewhere down the line, oxygen free radicals are likely to play a role.”
* Excerpt from Lori Oliwenstein’s article “The Oxygen Irony: Oxygen, the life force found in every breath, also is one of the human body’s most destructive invaders.” USC Health Magazine, 2002.
Eng3′s Activated Air device helps repair and prevent damage caused by oxidative stress.
A common misconception about the terms ‘aging’ and ‘anti-aging’ is that they only refer to living longer. Few credible remedies would claim to extend life. In fact any treatment that claims to extend life is immediately suspect. Far more realistic is the goal of positively influencing quality of life as people age. It seems ‘healthy-aging’ is a more fitting goal than ‘anti-aging’.
The average person’s life span has been getting longer – it has increased by decades during the last century. This is largely the result of reducing infant mortality and infectious diseases. Through science, it has also been possible to reduce early death due to heart problems and other conditions. Increasing life span, however, does not insure or even promote quality of life in later years. In fact, there are more older ill people than ever before. This fact suggests that there may be too much emphases on quantity of life and not enough consideration for quality of life. Statistics appear to confirm this, and it is certainly our experience at Eng3 Corporation. People commonly turn to Eng3’s Activated Air because they already suffer from one or more chronic disease. Our goal is to help people enjoy health and vitality for as long as they live and we are thrilled to see the growing number of people using Eng3’s Activated Air to maintain health and improve performance. Whether Activated Air is used for prevention or to recover form health problems, healthy aging is the key. See also The Growing Impact of Chronic Disease.
It is easy to incorporate Activated Air into a training regime . It can be done while you are using exercise equipment, like a treadmill, or during any activity where you can be comfortably connected to the device by the seven foot nasal cannula. During rigorous training, more time on the device is better. Using Activated Air for an hour before and an hour after strenuous workouts has worked well for a number Olympic athletes. It allows them to train harder, stay healthier and optimize their performance. Of course, most athletes or weekend warriors would use the device far less, ideally at least 20 minutes three or four times a week.
Healthy Aging featured an article in their e-newsletter by Kent Holterof, MD called “A Confounding Condition.” The article looks at the troubles with diagnosis and treatment, stating, “When it comes to treating patients with chronic fatigue syndrome (CFS) and fibromyalgia (FM), doctors are often at a loss.”
Holterof writes “Physicians need to employ a multi-system approach, instead of resorting to single-drug modalities for each symptom. This comprehensive approach is largely becoming the standard of care and is effective in 80 percent of patients with these conditions.”
His recommendations for a multi-system approach include 1) Stabilizing the patient; 2) Mitochondrial enhancement; 3) Balance the hormones; 4) Treat the infectious components; 5) Address unique etiologies; and 6) Maintenance.
Lets take closer look at component 2 – Mitochondrial enhancement.
Mitochondria within the cells produce energy (ATP).
Holterof states, “When the mitochondria are not working properly, the cells and tissues of the body are starved for energy. This abnormality may be the common endpoint for all the dysfunctions in CFS and FM.
Not only do the reduced amounts of metabolized glucose produce weight gain, reduced aerobic energy production requires the body to rely on anaerobic metabolism. This causes fatigue, muscle pain, poor concentration, gastrointestinal dysfunction, headaches and postexertional malaise.
….Mitochondria dysfunction has the greatest impact on the most active tissues, including the hypothalamus, pituitary, muscle, nerve and immune cells. These are the major dysfunctions of these conditions and can significantly explain the symptoms of CFS/FM.”
This relates to Eng3 because our technology specifically improves cell function, including mitochondria function to optimize cell energy production. Meaning, breathing Activated Air helps the mitochondria work properly.
Many people take supplements in an effort to support their health and nutrition, but putting nutrients into your body by no means ensures that they are absorbed and used. Elaborate supplementation can produce expensive urine but, unless the nutrients are properly absorbed, supplements will do little to enhance your health, nutrition, or to protect your system.
Proper utilization of nutrients is, of course, a protein function. As a result, Activated Air’s unique ability to support protein function ultimately improves the uptake of nutrients, both in the food we eat and supplements. Antioxidants are a common supplement and important nutrient. Because they help neutralize free radicals, they can help prevent damage caused by oxidative stress. However, antioxidants cannot repair oxidative stress damage. Proteins do this work. By breathing Activated Air, you are improving protein function, which both prevents and repairs free radical/oxidative stress damage.
Last month researchers at Vanderbilt University’s School of Medicine presented interesting results on fibromyalgia and oxidative stress. (1)
Because, as they put it, “Oxidative stress is thought to play a role in the pathogenesis of fibromyalgia” they investigated whether oxidative stress was higher in patients with fibromyalgia and if it was related to the severity of symptoms.
After evaluating 48 control patients with fibromyalgia and comparing them to 96 control subjects, they learned that the results were not entirely as expected. Oxidative stress was associated with fatigue, which is consistent with an earlier study on systemic lupus erythematosus. Additionally, fibromyalgia patients with significantly more fatigue had much higher levels of the oxidative stress marker. Other symptoms of fibromyalgia, however, were not correlated with the oxidative stress marker in this study.
Eng3′s Activated Air device is often used by people with fibromyalgia. Since better sleep is directly related to fatigue, it is not surprising that users are excited about Activated Air. As one enthusiastic customer puts it: “I have fibromyalgia and don’t have nearly the muscle pain I used to since using Activated Air. I am also sleeping better and am less tired.”
~Rose K., Ohio.
(1) “Oxidative stress in fibromyalgia and its relationship to symptoms.” Clinical Rheumatology, Chung CP et. al. December 17, 2008.
Stanford University School of Medicine conducted a study tracking 500 runners over the age of 50, for 20 years. The study was started at the beginning of the “jogging craze” when many believed the long term affects of running could lead to increased orthopedic problems, more wear-and-tear, and ultimately more disabilities as runners aged, as compared with similar non-runners.
The Standford study results seem to contradict these fears.The study found that the onset of disability was much later for runners than for nonrunners. “Runners’ initial disability was 16 years later than nonrunners….By and large, the runners have stayed healthy.” The study also notes that “ninteen years into the study, 34 percent of the nonrunners had died, compared to only 15 percent of the runners.”
Eng3 Corporation supports endurance athletes and casual runners alike with Activated Air technology. Athletes use it to improve energy levels before exercise and to recover faster after strenuous workouts. Breathing Activated Air promotes the body’s natural healing processes and improves physical fitness, muscle strength, and endurance. Activated Air combined with the natural benefits of running or other athletic activity, creates an unbeatable approach for fitness, vitality, and healthy aging.
Eliza F. Chakravarty, MD, MS; Helen B. Hubert, PhD; Vijaya B. Lingala, PhD; James F. Fries, MD. (2008) Reduced Disability and Mortality Among Aging Runners: A 21-Year Longitudinal Study. Arch Intern Med. 2008;168(15):1638-1646.
With all the great things that activated air can do for your body and your health, we are often asked if there are any negative side effects or contraindications.
Activated air does not contain any chemicals or drugs so it cannot conflict with medications. Because activated air helps improve cell metabolism and oxygen utilization, which means your cells will work better, it supports detoxification. People who are highly sensitive or highly toxic may experience a headache, feeling tired, or even diarrhea. People often report feeling more alert and some new users have trouble sleeping if they use the device too late at night. Once a person is accustomed to activated air, it can be used in the evening without interrupting sleep.
The safest thing is to start slowly when using the activated air device. Start out with 5 minutes and work up to a session of 20 minutes on the large device, or 40 minutes on the small one. Also, the more compromised your health is, the more gentle you should be- increasing the time even more gradually. But, as long as you feel okay, keep increasing the time until you get to a full session and longer. You can’t overuse the device once you have worked up to it, but you don’t want to feel uncomfortable by going too quickly.
Now that the holidays are over, many of us are feeling the effects of all the parties, family gatherings, work parties, and celebrating that come with the holiday season. Along with the increase in social activities there may be an increase in food and alcohol consumption. It is easy for people overindulge this time of year. Unfortunately, the effects of drinking too much alcohol are not only felt the next morning, or seen in the waistline, but may go much deeper, affecting our health and our body’s ability to manage oxidative stress.
An article by Wu and Cederbaum states “Alcohol promotes the generation of ROS and/or interferes with the body’s normal defense mechanisms against these compounds through numerous processes, particularly in the liver.” Alcohol impacts agents such as antioxidants that typically eliminate free radicals, and also can facilitate an increase in free radical production by altering the levels of certain metals in the body. So, alcohol contributes to the production of free radicals, which can result in oxidative stress. Too much oxidative stress can do damage to our bodies and is related to a host of diseases and disorders.
Regardless of the source of oxidative stress, Eng3′s Activated Air device is used to reduce its damage and improve cell metabolism. Because of this, it helps your body combat the ill effects of alcohol.
“Since many illnesses are the result of diminished oxygen utilization and oxidative stress damage such as excessive free radicals, inhaling air from the device improves the body’s use of oxygen, oxidative response, and defense against free radical damage. Ultimately, it promotes cell regeneration, protects against premature again and disease, boosts the immune system and provides sustainable energy for better overall health and vitality”
The oxygen metabolism is the major process involved in cell energy production. There are two main aspects of the oxygen metabolism: 
According to National Diabetes Information Clearinghouse (
