The oxygen metabolism is the major process involved in cell energy production. There are two main aspects of the oxygen metabolism: Oxidative Stress and Oxidative Response.

This White Paper briefly describes each of these terms and suggests search phrases that can be used to find more information on each topic. This discussion is followed by a brief explanation of how Activated Air relies on these natural processes to help the body increase cell energy production.

Oxidative Stress:
Oxidative Stress describes cell damage caused by an overabundance of oxidants, including reactive oxygen species (ROS). The two types of ROS are free radicals and activated oxygen species. ROS are harmful in excess, but some levels of them are necessary for important cell functions. For example, singlet oxygen, which is an activated oxygen species, is involved in cell signaling that triggers the Oxidative Response System within the cells.

ROS and Oxidative Stress cause aging as well as many diseases and disorders, including:

• Inflammatory skin diseases
• Cardiovascular diseases
• Autoimmune diseases
• Neurodegenerative diseases
• Mitochondrial diseases
• Diabetes
• Respiratory/Pulmonary diseases
• Cancer
• Chronic Fatigue Syndrome
• Alzheimer’s disease
• Huntington’s disease
• Parkinson’s disease
• Lou Gehrig’s disease
• Ischemia
• Hyperoxia
• Macular degeneration
• Other chronic diseases

To find additional related disorders please Google: Oxidative Stress and Oxidative Response together.

Oxidative Response:
The cellular defense against Oxidative Stress is the Oxidative Response. The Oxidative Response System (or cell response system) protects against, and repairs, Oxidative Stress damage. This is accomplished mainly through enzyme and coenzyme production. The Oxidative Response is initiated by signal transduction sequences induced by singlet oxygen. Singlet oxygen is an activated oxygen species, but not a free radical. Signaling proteins then trigger the cell response.

Cell response results include, but are not limited to:

• Protection against free radical damage
• Repair of damage caused by free radicals
• Improved Oxygen utilization
• Improved cell energy production
• Improved cell metabolism

For optimal cell metabolism, a strong Oxidative Response and low Oxidative Stress are essential.

The Solution:
Activated Air technology has a patented process that generates an activated oxygen species, in this case singlet oxygen, in a contained activation chamber within the device. This unstable singlet oxygen quickly reverts back to triplet oxygen. Relaxation energy is emitted and quenched to water molecules in air flowing through the activation chamber. This is the same process that occurs continuously in the watery environment within the
cells. Those water molecules, inside and outside of the cells, are understood to be vehicles for the signal transduction sequences. After inhalation, and in contact with cells, the signal transduction initiates the cell response and the cellular defense mechanism.

Areas of use of Activated Air technology:

• Prevention against any age-related disorders
• Biological and physiological improvements, where optimal cell energy production is needed (cell regeneration, cell rejuvenation, recovery)
• Physiological improvement for disorders caused by Oxidative Stress
• Physiological conditions that cause Oxidative Stress
• Hypertension Warning Signs

To find out more about a disorder that could be addressed with activated air, please contact www.eng3corp.com,  (877) 571-9206 or email info@eng3corp.com.

According to the Baltimore Sun, there is no doubt that “silver is the new green for the fitness industry.” An increasing number of people are working, and working out, to prevent a decline in mental and physical health as they age. The Sun puts it this way: “As the Woodstock generation rocks into their 60s, they are revolutionizing yet another aspect of society, the gym. Looking to maintain a healthy quality of life, members more than 55-years-old joined gyms over the past 15 years at double the rate of the 35 to 54 age group. Fitness centers looking to capture this lucrative older market are springing up all over the country.”

Currently these silver-friendly gyms are offering a more peaceful and less competitive environment, low impact equipment for cardio workouts and classes (as well as personal trainers) suited to older bodies. Some leading gyms are offering technology for improving brain skills. This type of service responds to the growing urgency of people trying to avoid Alzheimer’s or other forms of dementia as they age.

Overall, we can expect to see more fitness centers catering to aging baby boomers and more of these centers offering health solutions that extend far beyond exercise. Eng3′s Activated Air is an ideal fit for these fitness centers.

Analysis of heart rate variability (HRV) – a powerful diagnostic tool HRV analysis is a straightforward, quick and non-invasive diagnostic procedure which is scientifically based and recognized. “If a superordinate system controls and regulates subordinate systems, the operational state of the superordinate system is the most important parameter for diagnosing disorders!”

What is significant and unique about HRV analysis is its ability to display quickly, in a completely painfree, non-invasive and meaningful manner, the autonomic nervous system’s (ANS) capacity to regulate. See document below for the full story, visit Eng3Corp.com or call 877.571.9206.

Oxidative Stress and Diabetes

According to National Diabetes Information Clearinghouse (NDIC), Diabetes affects 23.6 million people-7.8 percent of the population- in the US. Like many other conditions, such as cardiovascular disease, the risk for developing type 2 diabetes increases with age and is most often diagnosed after the age of 45.

Many scientific disciplines, like biophysics and cell-biology, are involved in research and many publications about the disease are available and ongoing research will add. The knowledge about the mechanism of oxidative stress and diabetes is part of many biological researches. More in this article.

THE SOURCES AND THE TARGETS OF OXIDATIVE STRESS IN THE ETIOLOGY OF DIABETIC COMPLICATIONS Maria Mohora and her co-authors explain the relationship between oxidative stress and its medical implementation in form of diabetes. In short, oxidative stress is caused by an imbalance between the production of reactive oxygen, often called free radicals, and the oxidative response. The oxidative response in biological systems is able to readily detoxify the reactive intermediates or easily repair the resulting oxidative damage. It’s the cell’s protection shield against oxidative stress.

A biophysical approach, without drugs or other artificial substances, enables a new technology designed to improve oxidative response. Improving oxidative response is the focus of Eng3 Corporation and, with Eng3′s technology. Professionals in clinics as well as home users are addressing health problems caused by oxidative stress. This drug-free approach is available in Medical Clinics, Medispas and Wellness Centers that usually offer 20-minutes sessions. Home users can benefit from daily applications with their own device.

Learn more about oxidative stress treatment at Eng3Corp.com or call 877.571.9206.

Hans Eng, President and CEO, Eng3 Corporation

One of the most exciting topics in medical research is protein modulation. This approach, which is clinically known as redox therapy or signal transduction therapy, holds great promise for a wide array of health issues. Because of the great potential in this area of cell science, Eng3 Corporation worked with Indiana University School of Medicine to summarize the current state of the scientific knowledge. The results describe the mechanisms that lead to oxidative stress damage and consider innovative technical solutions such as redox and signal transduction therapies.

Cellular activities are completely reliant on the interaction within and between protein structures. In recent years, scientists have come to realize that the failure of communication-molecular miscommunication-can be blamed for many health disorders. “Most of our diseases are related to intra- and intercellular communication disorders,” write the editors of Current Signal Transduction Therapy. “The concept of signal transduction therapy has gotten into the front line of modern research, and a multidisciplinary approach is being used to identify and treat signaling disorders.”[1]

One of the main culprits behind cellular miscommunication is oxidative stress damage, which is known to damage protein structures and therefore leads to a decline in cellular activity. Recent advances in biophysics are now being applied to state-of-the-art technology in protein modulation. These innovations aim to improve cellular activity, fight oxidative stress damage, and enhance the proper functioning of cells’ signaling pathways. Such technology therefore stimulates and strengthens the body’s oxidative response, which:

• Preconditions the body’s defenses;
• Correctly interprets the build-up of free radicals as a signal to act;
• Counters oxidative stress and neutralizes (or scavenges) free radicals, by producing appropriate proteins and enzymes (antioxidants); and
• Minimizes cellular DNA damage.

Prof. Dr. Gabi Nindl Waite, a leading research scientist in Cellular and Integrative Physiology at Indiana University School of Medicine, writes: “The potential of redox therapies to become an important part of conventional medicine is recognized by many.”[2] There is great optimism that redox therapies may dramatically improve health care outcomes. Conventional and naturopathic doctors, sports medicine professionals, and anti-aging specialists are already embracing progressive solutions like the device provided by Eng3 Corporation.

The impact of protein modulation technology on cellular activity

Clinical studies have shown improved cellular activity helps cells utilize oxygen better, improve their metabolism, fight oxidative stress damage, and enhance regeneration. Studies have shown quantifiable evidence of:

• Increased heart rate variability (HRV) – the organism as a whole is healthier and all cellular processes are optimized;
• Significant growth of reserves for cellular activity and increased energetic-metabolic efficacy – both subjectively noticeable and objectively measurable;
• A decrease in organism stress – excessive stress-related damage is avoided;[3]
• A lower percentage of unused oxygen is exhaled – the body is better able to utilize oxygen on the cellular level; and
• A slower resting heart rate – cells perform faster and more efficiently.[4]

Of equal or perhaps greater significance is the fact that protein modulation technology will help people better manage age-related diseases and chronic disorders. People using these devices often report rapid and dramatic positive results, including:

• Reduced inflammation;
• Disappearance of pain and other symptoms related to chronic disorders;
• Shortened recovery time and faster cell regeneration;
• Improved sleep;
• Increased energy, better concentration, faster reflexes, and greater mental awareness;
• Improved vision and other age-related problems; and

• A renewed sense of well-being.

Current state of protein modulation research

Researchers at Indiana University School of Medicine, in collaboration with Eng3 Corporation, summarized the current state of scientific knowledge regarding the mechanisms leading to oxidative stress damage. The results, which consider solutions such as redox and signal transduction therapy, were published in the Journal of Cell Science.[5] A short synopsis of the work suggests that reactive oxygen species (ROS) have been identified as being responsible for many harmful events in humans and, on the other hand, they are increasingly being recognized as necessary cell signaling agents. The multiple roles of ROS are reflected in the multiple roles of antioxidants, which are part of many disease preventing remedies, but are recently discussed as disease causing agents. The publication provides an overview of the current knowledge of ROS as part of complex redox networks that can harm or benefit cells. It presents up-to-date physicochemical and biological information, in an understandable, novel way, to involve the reader in the significant discussion on ROS and anti-ROS as the novel therapeutic agents of the coming decades.

Eng3 Technology: Proven approach for improving cellular activity

Eng3′s technology applies advances in biophysics for protein modulation, to improve cell activity and therefore strengthen cell metabolism, including the cellular oxidative response. This improves the body’s functionality, or more precisely its biomolecules-in the form of proteins and enzymes. By using the body’s own oxidative response capability, and the thousands of powerful enzymes at its disposal, this approach can slow and even reverse the damage associated with oxidative stress, disease, and aging.

A German consortium of some of the leading research institutions in the world made a formal study of this technology. After concluding its analysis, they wrote of the possibilities for such technology in the strongest terms: “In light of the key role of enzymes in biochemical processes, this technology cannot be overestimated with regard to its significance for microbiological processes and metabolic operations.” Conventional medicine, the Institute continued, could make use of this technology to help treat a wide range of conditions, including respiratory problems, arteriosclerosis, arthritis, chronic disorders, and degenerative diseases.[6]

After collaborating with Eng3 Corporation for more than six months, Dr. Waite reached a similarly enthusiastic conclusion: “It is a fascinating time for this field of research since it contributes to new therapies, which will lead into a new therapeutic era. Any therapy that specifically regulates the concentration, conformation, quaternary structure, or the location of proteins would be of great benefit for a wide range of medical conditions. Eng3, as I understand it, is developing such novel human therapies.” ^2[7]

Prevention and restoration of physiological performance:

Patients can use Eng3′s patented, FDA-cleared device in integrated medical centers, advanced health clinics, centers for chronic disorders, sports centers, medispas, at the doctor’s office, and at home. Eng3 has both professional and home devices available. This therapy that can be used alone or with other treatments. For more information about Eng3′s Activated Air Technology, please contact Eng3 Corporation at 877.571.9206 or info@eng3corp.com.

[2] Dr. Gabi Nindl Waite, “Hydrogen Peroxide – From Oxidative Stressor to Redox Regulator,” Cellscience Reviews, Vol. 1, No. 2 (2004).

[3] Dr. Michael Kucera, “‘Active Air’ Inhalation Therapy: Autonomic Regulation Mechanisms with Use of Heart Rate Variability Analysis,” Explore! Volume 16, Number 2, 2007.

[4] Dr. Claudia Schöllmann, “Concentrated Oxygen  and Activated Respiratory Air: A Comparison Between the Physiological Effects of Two Inhalation Applications,” Germany. Explore! Volume 15, Number 2, 2006.

[5] From Redox Homeostasis to Protein Structure Modulation and Redox Signaling Therapy

Gabi N. Waite and Walter X. Balcavage, Indiana University School of Medicine, Journal of Cell Science 2009, available at www.cellscience.com/Reviews19/Redox_signaling.html or directly from Eng3 Corporation.

[6] Delta-Ge, a research consortium that included, Germany’s prestigious Fraunhofer Institute ISE

[7] Dr. Gabi Nindl Waite, Department of Cellular and Integrative Physiology, University School of Medicine, Terre Haute, IN 47809