Hans Eng, President and CEO, Eng3 Corporation

One of the most exciting topics in medical research is protein modulation. This approach, which is clinically known as redox therapy or signal transduction therapy, holds great promise for a wide array of health issues. Because of the great potential in this area of cell science, Eng3 Corporation worked with Indiana University School of Medicine to summarize the current state of the scientific knowledge. The results describe the mechanisms that lead to oxidative stress damage and consider innovative technical solutions such as redox and signal transduction therapies.

Cellular activities are completely reliant on the interaction within and between protein structures. In recent years, scientists have come to realize that the failure of communication-molecular miscommunication-can be blamed for many health disorders. “Most of our diseases are related to intra- and intercellular communication disorders,” write the editors of Current Signal Transduction Therapy. “The concept of signal transduction therapy has gotten into the front line of modern research, and a multidisciplinary approach is being used to identify and treat signaling disorders.”[1]

One of the main culprits behind cellular miscommunication is oxidative stress damage, which is known to damage protein structures and therefore leads to a decline in cellular activity. Recent advances in biophysics are now being applied to state-of-the-art technology in protein modulation. These innovations aim to improve cellular activity, fight oxidative stress damage, and enhance the proper functioning of cells’ signaling pathways. Such technology therefore stimulates and strengthens the body’s oxidative response, which:

• Preconditions the body’s defenses;
• Correctly interprets the build-up of free radicals as a signal to act;
• Counters oxidative stress and neutralizes (or scavenges) free radicals, by producing appropriate proteins and enzymes (antioxidants); and
• Minimizes cellular DNA damage.

Prof. Dr. Gabi Nindl Waite, a leading research scientist in Cellular and Integrative Physiology at Indiana University School of Medicine, writes: “The potential of redox therapies to become an important part of conventional medicine is recognized by many.”[2] There is great optimism that redox therapies may dramatically improve health care outcomes. Conventional and naturopathic doctors, sports medicine professionals, and anti-aging specialists are already embracing progressive solutions like the device provided by Eng3 Corporation.

The impact of protein modulation technology on cellular activity

Clinical studies have shown improved cellular activity helps cells utilize oxygen better, improve their metabolism, fight oxidative stress damage, and enhance regeneration. Studies have shown quantifiable evidence of:

• Increased heart rate variability (HRV) – the organism as a whole is healthier and all cellular processes are optimized;
• Significant growth of reserves for cellular activity and increased energetic-metabolic efficacy – both subjectively noticeable and objectively measurable;
• A decrease in organism stress – excessive stress-related damage is avoided;[3]
• A lower percentage of unused oxygen is exhaled – the body is better able to utilize oxygen on the cellular level; and
• A slower resting heart rate – cells perform faster and more efficiently.[4]

Of equal or perhaps greater significance is the fact that protein modulation technology will help people better manage age-related diseases and chronic disorders. People using these devices often report rapid and dramatic positive results, including:

• Reduced inflammation;
• Disappearance of pain and other symptoms related to chronic disorders;
• Shortened recovery time and faster cell regeneration;
• Improved sleep;
• Increased energy, better concentration, faster reflexes, and greater mental awareness;
• Improved vision and other age-related problems; and

• A renewed sense of well-being.

Current state of protein modulation research

Researchers at Indiana University School of Medicine, in collaboration with Eng3 Corporation, summarized the current state of scientific knowledge regarding the mechanisms leading to oxidative stress damage. The results, which consider solutions such as redox and signal transduction therapy, were published in the Journal of Cell Science.[5] A short synopsis of the work suggests that reactive oxygen species (ROS) have been identified as being responsible for many harmful events in humans and, on the other hand, they are increasingly being recognized as necessary cell signaling agents. The multiple roles of ROS are reflected in the multiple roles of antioxidants, which are part of many disease preventing remedies, but are recently discussed as disease causing agents. The publication provides an overview of the current knowledge of ROS as part of complex redox networks that can harm or benefit cells. It presents up-to-date physicochemical and biological information, in an understandable, novel way, to involve the reader in the significant discussion on ROS and anti-ROS as the novel therapeutic agents of the coming decades.

Eng3 Technology: Proven approach for improving cellular activity

Eng3′s technology applies advances in biophysics for protein modulation, to improve cell activity and therefore strengthen cell metabolism, including the cellular oxidative response. This improves the body’s functionality, or more precisely its biomolecules-in the form of proteins and enzymes. By using the body’s own oxidative response capability, and the thousands of powerful enzymes at its disposal, this approach can slow and even reverse the damage associated with oxidative stress, disease, and aging.

A German consortium of some of the leading research institutions in the world made a formal study of this technology. After concluding its analysis, they wrote of the possibilities for such technology in the strongest terms: “In light of the key role of enzymes in biochemical processes, this technology cannot be overestimated with regard to its significance for microbiological processes and metabolic operations.” Conventional medicine, the Institute continued, could make use of this technology to help treat a wide range of conditions, including respiratory problems, arteriosclerosis, arthritis, chronic disorders, and degenerative diseases.[6]

After collaborating with Eng3 Corporation for more than six months, Dr. Waite reached a similarly enthusiastic conclusion: “It is a fascinating time for this field of research since it contributes to new therapies, which will lead into a new therapeutic era. Any therapy that specifically regulates the concentration, conformation, quaternary structure, or the location of proteins would be of great benefit for a wide range of medical conditions. Eng3, as I understand it, is developing such novel human therapies.” ^2[7]

Prevention and restoration of physiological performance:

Patients can use Eng3′s patented, FDA-cleared device in integrated medical centers, advanced health clinics, centers for chronic disorders, sports centers, medispas, at the doctor’s office, and at home. Eng3 has both professional and home devices available. This therapy that can be used alone or with other treatments. For more information about Eng3′s Activated Air Technology, please contact Eng3 Corporation at 877.571.9206 or info@eng3corp.com.

[2] Dr. Gabi Nindl Waite, “Hydrogen Peroxide – From Oxidative Stressor to Redox Regulator,” Cellscience Reviews, Vol. 1, No. 2 (2004).

[3] Dr. Michael Kucera, “‘Active Air’ Inhalation Therapy: Autonomic Regulation Mechanisms with Use of Heart Rate Variability Analysis,” Explore! Volume 16, Number 2, 2007.

[4] Dr. Claudia Schöllmann, “Concentrated Oxygen  and Activated Respiratory Air: A Comparison Between the Physiological Effects of Two Inhalation Applications,” Germany. Explore! Volume 15, Number 2, 2006.

[5] From Redox Homeostasis to Protein Structure Modulation and Redox Signaling Therapy

Gabi N. Waite and Walter X. Balcavage, Indiana University School of Medicine, Journal of Cell Science 2009, available at www.cellscience.com/Reviews19/Redox_signaling.html or directly from Eng3 Corporation.

[6] Delta-Ge, a research consortium that included, Germany’s prestigious Fraunhofer Institute ISE

[7] Dr. Gabi Nindl Waite, Department of Cellular and Integrative Physiology, University School of Medicine, Terre Haute, IN 47809