Many people have found benefit to using Activated Air while they sleep. Activated Air devices with software version 1.2 or higher have a continuous operation setting, enabling the device to run all night long without having to restart a session. To see which software version you have – turn your device on – while it runs through the self test the software version number will display in the lower right corner. If it is 1.2 or higher, follow the directions below.

Changing settings to continuous operation: (more…)

Although it is known that the growth of cancerous tumors is impacted by the buildup of free radicals, treatments using anti-oxidants or pro-oxidants have had mixed results, according to a paper posted by the University of Michigan, because of the way patients differ in their oxidative stress levels.

“Being able to monitor a marker of oxidative stress that is associated with the activation of tumor cell growth pathways, particularly at an early stage, and then tailor treatments accordingly would allow for more targeted studies and might improve the odds of success with antioxidants and pro-oxidants,” says University of Michigan chemical biologist Kate Carroll.

Carroll and colleagues have developed a method to detect oxidative stress assessing “sulfenic acid in proteins – a tipoff to early oxidative stress and to a specific protein modification associated with cell growth pathways.” The sulfenic acid makes patterns which indicate varying levels of oxidative stress.

“Whether the patterns we see will correlate with response to antioxidant treatment or other therapies that modulate oxidative stress level remains to be seen, but now we at least have a way to investigate that question” says Carroll.

In the future, Carroll intends to determine which specific proteins play a role in the disease process, and she anticipates that many proteins are involved.

http://www.ns.umich.edu/htdocs/releases/story.php?id=7294

Eng3 is excited to be doing our part to help the planet. We have converted our packing materials for the Activated Air devices to use more recyclable materials and less foam. We’ve even reduced packaging from three boxes down to one.  Ensuring our Activated Air devices arrive safe and sound is top priority, so it was no easy task to find a way to use less foam while still meeting our standards for shipping protection. But we found a way! The changes we’ve made mean there is less to go into the recycle bin, and minimal to toss into the garbage.

The mechanism of how oxidative stress causes damage and its underlying role in aging is documented in many studies. The medical implications of damage that leads to chronic disorders are increasingly being published and can be found when searching: oxidative stress “disease name” (ex: oxidative stress asthma).

In biophysics and cell-biology the process that involves proteins to protect against oxidative stress damage is known as oxidative response. The fact is that oxidative stress damages proteins and damaged proteins have a diminished repair capability.

This important repair mechanism for RNA and DNA is described in detail in the Journal of Biomedicine and Biotechnology: Oxidative Damage to RNA in Neurodegenerative Diseases

Nunomura et al. describe the importance of the repair mechanism for RNA. If the repair mechanism is diminished it can lead to neurodegenerative diseases including Alzheimer’s disease, Parkinson’s disease, Down syndrome, Dementia with Lewy Bodies, and Prion disease. In detail they explain the involvement of proteins in enzymatic reactions that are responsible for protection against oxidative stress and summarize it:

“Furthermore, cells have mechanism of dealing with nucleotide damage other than direct repair, which seems to be useful for defense against oxidative damage to both DNA and RNA.”

At ENG3 Corporation, our focus is to design devices that improve oxidative response.  A biophysical treatment is available with Eng3’s technology, which is drug-free and extremely easy to use. Addressing protein structure is being implemented in medical clinics, medi-spas and wellness centers. Home users are also using it to address age-related disorders and as a breakthrough prevention tool.

Researchers at the University of Cambridge have determined the role of a protein called Nanog. It’s been known for several years that Nanog is a key player “in the system that keeps stem cells in a constant, undifferentiated ‘pluripotent’ form.”

But in a recent study, researchers found that “Nanog acts like a conductor in charge of an orchestra of genes and proteins during the final performance. All must play at the right time in perfect harmony for the cell to ‘refresh’ into a pluripotent state. Without Nanog, a stem cell cannot maintain an immortal pluripotent state….The protein must be present during the final reprogramming phase when other key factors are already present, otherwise the cell becomes ’stuck’ in a halfway state of development.”

This is yet another example of the importance of protein function – if the Nanog protein is not functioning properly, stem cells do not develop correctly. All the more reason to support protein function. You may be interested to read Eng3’s Activated Air blog: Stem Cell Transplants and Oxidative Stress

Source: 2009, August 24. Discovery reveals more about stem cells’ immortality. Wellcome Trust. http://www.wellcome.ac.uk/News/2009/WTX056296.htm

Cellular activity is the entire orchestra of protein functions. While many protein functions are understood and recognized, the majority are not. The proteins involved in cellular activity are constantly being deciphered, explored and researched. Right now, the importance of the protein structure for protein function is well known, and innovative technologies are designed to improve the protein structure. With this growing knowledge we are able to address aging and health issues.

When cellular activity declines it means protein functions are not running as properly as they once did. Reduced cellular activity is more or less recognizable. On the mayo clinic website, examples of declining functions and their consequences are presented – see “Aging: What to expect as you get older” at http://www.mayoclinic.com/health/aging/HA00040

Most of today’s solutions for declining cellular activity are based on the approach to add more proteins to the body. These proteins could be hormones, enzymes, co-enzymes and even entire stem cells with thousands of different proteins in them. Other approaches attempt to reduce the causes leading to the decline in function, especially those that lead to damage of the protein structure. By far the most innovative approach is to improve the protein structure and consequently, cellular activity, through biophysical technologies. Improving the damage of protein structure results in the broadest improvement in cellular activity and is implemented by anti-aging and healthy-aging conscious users.

Eng3 Corporation is focused on improving cellular activity through a drug-free, biophysical approach. For more information please visit: www.eng3corp.com