Diabetes affects 23.6 million people—7.8 percent of the population— in the US, according to National Diabetes Information Clearinghouse (NDIC). Like many other conditions, such as cardiovascular disease, the risk for developing type 2 diabetes increases with age and is most often diagnosed after the age of 45.
Many scientific disciplines, like biophysics and cell-biology, are involved in research and many publications about the disease are available and ongoing research will add. The knowledge about the mechanism of oxidative stress and diabetes is part of many biological research projects. In this article: The Sources and the Targets of Oxidative Stress in the Etiology of Diabetic Complicationsby Maria Mohora and her coauthors, Maria Greabu, Corina Muscurel, Carmen Duta and Alexandra Totan, oxidative stress and its role in diabetes is explained. In short, oxidative stress is caused by an imbalance between the production of reactive oxygen, often called free radicals, and the body’s oxidative response. The oxidative response in biological systems repairs oxidative damage and is the cell’s protection shield against oxidative damage. When oxidative damage increases, cellular activities decline and with a strong oxidative response means cellular activities are high.
Without drugs or other artificial substances, a biophysical approach makes it possible to design new technology for improving oxidative response. Improving oxidative response, and therefore improving cellular activity, is the focus of Eng3 Corporation. Professionals in clinics, in spas and wellness centers, offer Eng3’s technology as a way to raise immune systems. People at home who benefit from daily use of their own activated air device also use the drug-free treatment. Eng3’s technology is a breakthrough, biophysical approach. A recent innovation by German, Canadian and US engineers working for Eng3 allowed the company to introduce direct excitation (called direct photo induction) in the latest technology. Older devices relied on a catalyst. The newest approach eliminates both the possibility of direct exposure to the catalyst material and the output variability associated with an imprecise catalyst. The result is higher excitation performance per time unit. Technological advances make it possible to optimally trigger the body’s natural response to oxidative stress.
Eng3 Corporation is located in Seattle, Washington and has been serving professional and home users since 2003. For more information about Eng3 technology, call 877 571-9206 or email info@eng3corp.com. Information is also available at Eng3’s website: www.eng3corp.com
One of the key complaints patients share with me as a bodyworker is a lack of energy. This can be an absence of verve to struggle through a gym workout or an exhaustion they lug home with them every night. Many complain they have just enough energy to work and no creative juice left over for their own projects. From the years 2001 to 2009, I developed a new type of bodywork to intervene deep in boney-vascular system called bone whispering which, along with the use of Eng3’s Activated Air device, addresses this problem. I have used this combination with over 500 patients and 90% of the time it produces a fountain of life energy for my patients.
This entirely new approach called Bone Whispering, and its intervention technique called Vascular Bone Therapy uses Activated Air and percussors to work deep in the bones to release what I call vascular bone spasms. (See websites below for more thorough descriptions.) I believe this stimulates life energy because it makes the bones (which are 40% collagen or connective tissue) springier and thus more alive. As a result of this youthful bounce, the marrow within the springy bones produces more hemoglobin which absorbs more oxygen, the fascial tissue enlivens the cells and the entire body brims with more vitality
One of the major elements of this energy shift is the Activated Air device. When I first bought my Activated Air device from Eng3 four years ago I began inhaling it ½ hour a day. At the end of a week of this my wife and I went to the Olympic Peninsula for a hike up Colonel Dan’s peak. It was a difficult route, one we had done before with a vertical of 4400 ft. and a rocky trail. As the climb proceeded I couldn’t believe my energy, I was bounding up the mountain! My wife kept falling behind and I would practically jog in place waiting for her. By the time we finished she couldn’t stand me. Even after a 5 hour hike I was not tired or sore. In fact, my surgically repaired left knee was not painful then or the next day. The last time I had done the hike I could hardly walk in the morning. I know the improvement was the Activated Air in my system.
Combining springy bones with Activated Air is a powerful elixir. I never would have thought bones and oxygen uptake could affect energy so overwhelmingly. I recommend this dual therapy to all my patients who want to be active and creative but just don’t have the vitality they need. No one ever has too much life energy!
My website: www.bonewhisperer.net has more information about Vascular Bone Therapy (VBT) and the bone whispering approach. Information about the Activated Air device I use is at Eng3 Corporation’s website: www.eng3corp.com
Researchers at the University of Cambridge have determined the role of a protein called Nanog. It’s been known for several years that Nanog is a key player “in the system that keeps stem cells in a constant, undifferentiated ‘pluripotent’ form.”
But in a recent study, researchers found that “Nanog acts like a conductor in charge of an orchestra of genes and proteins during the final performance. All must play at the right time in perfect harmony for the cell to ‘refresh’ into a pluripotent state. Without Nanog, a stem cell cannot maintain an immortal pluripotent state….The protein must be present during the final reprogramming phase when other key factors are already present, otherwise the cell becomes ‘stuck’ in a halfway state of development.”
This is yet another example of the importance of protein function – if the Nanog protein is not functioning properly, stem cells do not develop correctly. All the more reason to support protein function. You may be interested to read Eng3′s Activated Air blog: Stem Cell Transplants and Oxidative Stress
Source: 2009, August 24. Discovery reveals more about stem cells’ immortality. Wellcome Trust. http://www.wellcome.ac.uk/News/2009/WTX056296.htm
According to the Baltimore Sun, there is no doubt that “silver is the new green for the fitness industry.” An increasing number of people are working, and working out, to prevent a decline in mental and physical health as they age. The Sun puts it this way: “As the Woodstock generation rocks into their 60s, they are revolutionizing yet another aspect of society, the gym. Looking to maintain a healthy quality of life, members more than 55-years-old joined gyms over the past 15 years at double the rate of the 35 to 54 age group. Fitness centers looking to capture this lucrative older market are springing up all over the country.”
Currently these silver-friendly gyms are offering a more peaceful and less competitive environment, low impact equipment for cardio workouts and classes (as well as personal trainers) suited to older bodies. Some leading gyms are offering technology for improving brain skills. This type of service responds to the growing urgency of people trying to avoid Alzheimer’s or other forms of dementia as they age.
Overall, we can expect to see more fitness centers catering to aging baby boomers and more of these centers offering health solutions that extend far beyond exercise. Eng3′s Activated Air is an ideal fit for these fitness centers.
One of the most exciting topics in medical research is protein modulation. This approach, which is clinically known as redox therapy or signal transduction therapy, holds great promise for a wide array of health issues. Because of the great potential in this area of cell science, Eng3 Corporation worked with Indiana University School of Medicine to summarize the current state of the scientific knowledge. The results describe the mechanisms that lead to oxidative stress damage and consider innovative technical solutions such as redox and signal transduction therapies.
Cellular activities are completely reliant on the interaction within and between protein structures. In recent years, scientists have come to realize that the failure of communication-molecular miscommunication-can be blamed for many health disorders. “Most of our diseases are related to intra- and intercellular communication disorders,” write the editors of Current Signal Transduction Therapy. “The concept of signal transduction therapy has gotten into the front line of modern research, and a multidisciplinary approach is being used to identify and treat signaling disorders.”[1]
One of the main culprits behind cellular miscommunication is oxidative stress damage, which is known to damage protein structures and therefore leads to a decline in cellular activity. Recent advances in biophysics are now being applied to state-of-the-art technology in protein modulation. These innovations aim to improve cellular activity, fight oxidative stress damage, and enhance the proper functioning of cells’ signaling pathways. Such technology therefore stimulates and strengthens the body’s oxidative response, which:
Preconditions the body’s defenses;
Correctly interprets the build-up of free radicals as a signal to act;
Counters oxidative stress and neutralizes (or scavenges) free radicals, by producing appropriate proteins and enzymes (antioxidants); and
Minimizes cellular DNA damage.
Prof. Dr. Gabi Nindl Waite, a leading research scientist in Cellular and Integrative Physiology at Indiana University School of Medicine, writes: “The potential of redox therapies to become an important part of conventional medicine is recognized by many.”[2] There is great optimism that redox therapies may dramatically improve health care outcomes. Conventional and naturopathic doctors, sports medicine professionals, and anti-aging specialists are already embracing progressive solutions like the device provided by Eng3 Corporation.
The impact of protein modulation technology on cellular activity
Clinical studies have shown improved cellular activity helps cells utilize oxygen better, improve their metabolism, fight oxidative stress damage, and enhance regeneration. Studies have shown quantifiable evidence of:
Increased heart rate variability (HRV) – the organism as a whole is healthier and all cellular processes are optimized;
Significant growth of reserves for cellular activity and increased energetic-metabolic efficacy – both subjectively noticeable and objectively measurable;
A decrease in organism stress – excessive stress-related damage is avoided;[3]
A lower percentage of unused oxygen is exhaled – the body is better able to utilize oxygen on the cellular level; and
A slower resting heart rate – cells perform faster and more efficiently.[4]
Of equal or perhaps greater significance is the fact that protein modulation technology will help people better manage age-related diseases and chronic disorders. People using these devices often report rapid and dramatic positive results, including:
Reduced inflammation;
Disappearance of pain and other symptoms related to chronic disorders;
Shortened recovery time and faster cell regeneration;
Improved sleep;
Increased energy, better concentration, faster reflexes, and greater mental awareness;
Improved vision and other age-related problems; and
A renewed sense of well-being.
Current state of protein modulation research
Researchers at Indiana University School of Medicine, in collaboration with Eng3 Corporation, summarized the current state of scientific knowledge regarding the mechanisms leading to oxidative stress damage. The results, which consider solutions such as redox and signal transduction therapy, were published in the Journal of Cell Science.[5] A short synopsis of the work suggests that reactive oxygen species (ROS) have been identified as being responsible for many harmful events in humans and, on the other hand, they are increasingly being recognized as necessary cell signaling agents. The multiple roles of ROS are reflected in the multiple roles of antioxidants, which are part of many disease preventing remedies, but are recently discussed as disease causing agents. The publication provides an overview of the current knowledge of ROS as part of complex redox networks that can harm or benefit cells. It presents up-to-date physicochemical and biological information, in an understandable, novel way, to involve the reader in the significant discussion on ROS and anti-ROS as the novel therapeutic agents of the coming decades.
Eng3 Technology: Proven approach for improving cellular activity
Eng3′s technology applies advances in biophysics for protein modulation, to improve cell activity and therefore strengthen cell metabolism, including the cellular oxidative response. This improves the body’s functionality, or more precisely its biomolecules-in the form of proteins and enzymes. By using the body’s own oxidative response capability, and the thousands of powerful enzymes at its disposal, this approach can slow and even reverse the damage associated with oxidative stress, disease, and aging.
A German consortium of some of the leading research institutions in the world made a formal study of this technology. After concluding its analysis, they wrote of the possibilities for such technology in the strongest terms: “In light of the key role of enzymes in biochemical processes, this technology cannot be overestimated with regard to its significance for microbiological processes and metabolic operations.” Conventional medicine, the Institute continued, could make use of this technology to help treat a wide range of conditions, including respiratory problems, arteriosclerosis, arthritis, chronic disorders, and degenerative diseases.[6]
After collaborating with Eng3 Corporation for more than six months, Dr. Waite reached a similarly enthusiastic conclusion: “It is a fascinating time for this field of research since it contributes to new therapies, which will lead into a new therapeutic era. Any therapy that specifically regulates the concentration, conformation, quaternary structure, or the location of proteins would be of great benefit for a wide range of medical conditions. Eng3, as I understand it, is developing such novel human therapies.” 2[7]
Prevention and restoration of physiological performance:
Patients can use Eng3′s patented, FDA-cleared device in integrated medical centers, advanced health clinics, centers for chronic disorders, sports centers, medispas, at the doctor’s office, and at home. Eng3 has both professional and home devices available. This therapy that can be used alone or with other treatments. For more information about Eng3′s Activated Air Technology, please contact Eng3 Corporation at 877.571.9206 or info@eng3corp.com.
[2] Dr. Gabi Nindl Waite, “Hydrogen Peroxide – From Oxidative Stressor to Redox Regulator,” Cellscience Reviews, Vol. 1, No. 2 (2004).
[3] Dr. Michael Kucera, “‘Active Air’ Inhalation Therapy: Autonomic Regulation Mechanisms with Use of Heart Rate Variability Analysis,” Explore! Volume 16, Number 2, 2007.
[4] Dr. Claudia Schöllmann, “Concentrated Oxygen and Activated Respiratory Air: A Comparison Between the Physiological Effects of Two Inhalation Applications,” Germany. Explore! Volume 15, Number 2, 2006.
[5] From Redox Homeostasis to Protein Structure Modulation and Redox Signaling Therapy
Gabi N. Waite and Walter X. Balcavage, Indiana University School of Medicine, Journal of Cell Science 2009, available at www.cellscience.com/Reviews19/Redox_signaling.html or directly from Eng3 Corporation.
[6] Delta-Ge, a research consortium that included, Germany’s prestigious Fraunhofer Institute ISE
[7] Dr. Gabi Nindl Waite, Department of Cellular and Integrative Physiology, University School of Medicine, Terre Haute, IN 47809
Activated Air is a proven technology used by professional and individuals who want to enhance athletic performance, promote healthy aging or restore health. Eng3’s approach is to trigger the body’s natural response to oxidative stress and improve cellular activities like cell metabolism and the uptake of oxygen. Your body’s cells through the course of your life go through disease, aging and stress. Learn more about Motality with pulmonary hypertension and treatment for diseases of the respiratory system with Eng3.
The conversion of O2 gets weaker and weaker as we age deviating you from your optimum level…organs and cells do not get the optimum amount of energy and our metabolic system slows down. As an adult there is an aggressive increase in free radicals and the aging process is accelerated.
Improved cellular activity leads to better cell metabolism including cell energy production. It; enables peak mental and physical, performance, supports the immune system and prevents diseases and promotes healthy aging.
Activated Air helps to increase your body’s ability to absorb oxygen for a more efficient oxygen metabolism. Your body’s energy budget is improved, metabolism is stimulated and the bodies self-healing and regeneration powers are accelerated. Rejuvenated and revitalized cells are the best foundation for protecting and fighting against age-related health problems and disorders caused by inefficient energy production.
The benefits of improved cell performance are confirmed with test results. Heart Rate Variability, which is a measure of your underlying health is an easy way for doctors or individuals to measure improvement. Numerous more specific tests can be used to show results. Some of these tests are identified here at http://www.eng3corp.com
Department of Clinical and Biomedical Sciences, Barwon Health, University of Melbourne, Geelong, VIC, Australia. felicitn@barwonhealth.org.au
Oxidative stress has been implicated in the pathogenesis of diverse disease states, and may be a common pathogenic mechanism underlying many major psychiatric disorders, as the brain has comparatively greater vulnerability to oxidative damage. This review aims to examine the current evidence for the role of oxidative stress in psychiatric disorders, and its academic and clinical implications.
Oxidative stress is caused by an imbalance between the production of reactive oxygen and a biological system’s ability to readily detoxify the reactive intermediates or easily repair the resulting damage. All forms of life maintain a reducing environment within their cells. This reducing environment is preserved by enzymes that maintain the reduced state through a constant input of metabolic energy. Disturbances in this normal redox state can cause toxic effects through the production of peroxides and free radicals that damage all components of the cell, including proteins, lipids, and DNA.
A literature search was conducted using the Medline, Pubmed, PsycINFO, CINAHL PLUS, BIOSIS Preview, and Cochrane databases, with a time-frame extending to September 2007. The broadest data for oxidative stress mechanisms have been derived from studies conducted in schizophrenia, where evidence is available from different areas of oxidative research, including oxidative marker assays, psychopharmacology studies, and clinical trials of antioxidants. For bipolar disorder and depression, a solid foundation for oxidative stress hypotheses has been provided by biochemical, genetic, pharmacological, preclinical therapeutic studies and one clinical trial. Oxidative pathophysiology in anxiety disorders is strongly supported by animal models, and also by human biochemical data. Pilot studies have suggested efficacy of N-acetylcysteine in cocaine dependence, while early evidence is accumulating for oxidative mechanisms in autism and attention deficit hyperactivity disorder. In conclusion, multi-dimensional data support the role of oxidative stress in diverse psychiatric disorders. These data not only suggest that oxidative mechanisms may form unifying common pathogenic pathways in psychiatric disorders, but also introduce new targets for the development of therapeutic interventions.
PMID: 18205981 [PubMed - indexed for MEDLINE]
Click here to learn more about oxidative stress and the risk and preventive factors for mental health disorders,
The U.S. Centers for Disease Control and Prevention’s outlook for 2009 highlights the reasons for concern about health care in America. In the document: Healthy Aging: Improving and Extending Quality of Life Among Oder Americans, the CDC notes the implications of the aging population. It is clearly more important than ever for people to take any measures they can to promote healthy aging. The excerpt below on healthy aging paints a telling picture.
At A Glance 2009
The Health and Economic Effects of an Aging Society
By 2030, the number of U.S. adults aged 65 years or older will more than double to about 71 million. The rapidly increasing number and diversity of older Americans has far-reaching implications for the U.S. public health system and will place unprecedented demands on aging services and the nation’s entire health care system.
For example, Medicare spending has grown about nine-fold in the past 25 years, increasing from $37 billion in 1980 to $336 billion in 2005. If left unchecked, health care spending will increase 25% by 2030, largely because of the aging population.
Chronic diseases disproportionately affect older adults and are associated with disability, diminished quality of life, and increased costs for health care and long-term care. Today, about 80% of older adults have at least one chronic condition, and 50% have at least two. These conditions can cause years of pain and loss of function. Public health efforts can help Americans avoid preventable illness and disability as they age. Research has shown that poor health is not an inevitable consequence of aging. Effective public health strategies currently exist to help older adults remain independent longer, improve their quality of life, and potentially delay the need for long-term care.
Source: Centers for Disease Control and Prevention, http://cdc.gov/
In 2008 the American Journal of Biochemistry and Biotechnology released a special issue on Autism Spectrum Disorders (Vol 4, No. 2). Many studies in the issue provided evidence to support the concept of oxidative stress in autism. In fact, three separate studies showed increased oxidative damage in brain tissues from autistic subjects. Several articles looked at metal toxicity, including how lead and mercury can induce oxidative stress. A review of two articles also focused on the concept of mitochondrial dysfunction and how this can increase oxidative stress in autism.
The editor, Abha Chauhan writes, “Increased oxidative stress in autism may lead to membrane lipid abnormalities, altered cellular signal transduction, mitochondiral dysfunction, abnormal energy metabolism, excitotoxicity, inflammation and immune dysregulation in autism. These abnormalities may then contribute to abnormal brain development and function resulting in a spectrum of clinical manifestations in autism.”
Research in the field of Autism highlights the complexity of the disease and its treatment. Taking action to reduce oxidative should be a priority because oxidative stress plays a key role in Autism and a myriad of other illnesses. Learn more about this on the Need page.
Danish scientists have shown that particulate air pollution increases oxidative stress-induced DNA damage. Their investigation concludes that “Oxidative stress-induced DNA damage appears to an important mechanism of action of urban particulate air pollution.” The authors also state that “Exposure to ambient air particulate matter (PM) is associated with pulmonary and cardiovascular diseases and cancer.”*
Common sense tells us that air pollution is not good for us. However, these authors identify a number of ways that reactive oxygen species can be generated by particulate air pollution, which leads to oxidative stress damage. The Danish team found overwhelming evidence, based on three different types of experiments, that exposure to diesel exhaust and diesel exhaust particles causes oxidative DNA damage.
Unfortunately much of the world’s population already lives in a polluted environment and we are seeing the results show up in the rise of oxidative stress-related diseases. A previous post discusses the remarkable increase in chronic diseases. Read more about oxidative stress- related diseases at Eng3′s Need page.
*Oxidative stress-induced DNA damage by particulate air pollution.
Risom L, Møller P, Loft S. Institute of Public Health, University of Copenhagen, Øster Farimagsgade 5, 1014 Copenhagen K, Denmark.
Sleep Apnea (or Sleep Apnoea), a condition where people stop breathing for periods of 10 seconds or longer while sleeping, affects up to 18 million people in the US. Interference in breathing reduces the amount of oxygen in the blood. Eventually this lack of oxygen triggers the lungs to suck in air, causing gasping or snorting, and for the person to move to a lighter stage of sleep, or sometimes to wake up.
Sleep apnea is associated with serious heart and circulatory problems including hypertension (high blood pressure) and heart disease, as well as asthma, diabetes, kidney failure, peripheral nerve damage, seizures, epilepsy, and other nerve disorders.
Adults suffering from sleep apnea may experience excessive daytime sleepiness, headaches, irritability, reduced concentration and impaired mental/emotional functioning. Essentially they are not getting deep, restful sleep and enough oxygen at night, which has significant effect on mental and emotional wellbeing, and health.
People who suffer from sleep apnea use Eng3′s device for several reasons:
1) At the cellular level, Eng3 technology is improving cell metabolism so cells utilize oxygen better. When using Eng3 technology, those who suffer from sleep apnea will be using oxygen better both while awake and while sleeping.
2) Improved cell metabolism and oxygen utilization contributes to improved concentration during the day and better sleep at night.
You may be interested in a study on Sleep Apnea done with our technology by Marion Burmann-Urbanek, M.D., and Hendrik Straube, M.D. Learn more about the physical symptoms of anxiety and stress and sleep apnea treatment with Activated Air.
Hans Eng, founder and CEO or Eng3 Corporation, will be speaking to the Arizona Homeopathic and Integrative Medical Association (AHIMA) on Wednesday April 1st in Phoenix Arizona. His presentation entitled The Role of Oxidative Stress in Cellular Activity and Protein Structure Modulation: A state-of-the-art approach for Performance and Health draws on his research which focuses on how to biophysically influence cellular activity, without the use of chemicals or pharmaceuticals. State-of-the-art technology works with the fundamental components that enable cellular activity, including microbiological processes and metabolic operations. Eng3’s technology is implemented where prevention and restoration of the cellular activity is the focus, either for protection, repair or improvement of the entire orchestra of cellular activity or for a particular segment of cellular activities. Eng3’s latest research initiative was done with the University of Indiana, School of Medicine. The resulting publication is available at www.cellscience.com/Reviews19/Redox_signaling.html
Hans Eng
About Hans Eng
Hans-Joachim Eng, Founder and CEO of Eng3 Corporation (www.eng3corp.com)
He holds an advanced degree in Mechanical Engineering and Material Science from the Technical University of Berlin. Before founding Eng3 Corporation, Hans owned and ran a German-based company that designed and produced human implants with a focus on the biophysical optimization to bone and tissue cells. He also managed quality assurance and production for the human implant division at Johnson & Johnson Corporation, and before that at Mecron GmbH.
Meeting details:
AHIMA Meeting
Wednesday April 1st 7:00 pm to 8:30 pm
Moon Valley Country Club
151 West Moon Valley Drive
Phoenix, AZ 85023 Contact Eng3 Corporation at 877.571.9206 for more information
March 21 , 2009 is World Down Syndrome Day and brings our attention to related conditions common in people with Down Syndrome (DS).
Although the cause of Down Syndrome has long been known to be a chromosomal disorder, interesting research is looking at conditions that occur in individuals with Down Syndrome. Such conditions include the development of Alzheimer like symptoms in their 30′s and 40′s, as well as the fact the “the incidence of autoimmune diseases and cataracts is significantly increased, and the overall ageing process is accelerated.” (Jonavic et al, 1998).
The authors suggest that these conditions are related to high levels of oxidative stress in Down Syndrom patients. After studying 166 subjects they concluded that their “results provide direct evidence for increased oxidative stress in individuals with DS.”
Eng3′s Activated Air device is designed to help cells repair and protect against damage caused by oxidative stress. By supporting the immune system and the body’s natural response to oxidative stress, Eng3′s Activated Air may be a good fit for people with DS.
Biomarkers of oxidative stress are significantly elevated in Down syndrome. Jovanovic S.V., Clements D., MacLeod K., Free Radic Biol Med. 1998 Dec;25(9):1044-8.
During 2008, Eng3 collaborated with the University of Indiana, School of Medicine to create a comprehensive overview of the state of scientific research in protein modulation. This research project produced excellent results including the articulation of connections between different areas of related science. The reference and introduction to the resulting publication is below.
From redox homeostasis to protein structure modulation and redox signaling therapy
Gabi N. Waite, Dept. of Cellular & Integrative Physiology & Walter X. Balcavage, Dept. of Biochemistry & Molecular Biology , Indiana University School of Medicine, Terre Haute, IN 47809, USA.
Reactive oxygen species (ROS) have been identified as being responsible for many harmful events in humans, while on the other hand, they are increasingly being recognized as necessary cell signaling agents. The multiple roles of ROS are reflected in the multiple roles of antioxidants, which are part of many disease preventing remedies, but are recently also discussed as disease causing agents. This article provides an overview of the current knowledge of ROS as part of complex redox networks that can harm or benefit cells. It presents up-to-date physicochemical and biological information, in an understandable, novel way, to involve the reader in the significant discussion on ROS and anti-ROS as the novel therapeutic agents of the coming decades.
The Centers for Medicare and Medicaid Services, known as CMS, released a report on the state of the US health care system. The current state of health care and, even more importantly the forecasts, make it abundantly clear that individuals should do everything possible to maintain good health. Some of the more interesting data from the CMS report are summarized below.
The share of the economy devoted to health spending will increase by a percentage point from 2008. This would represent the biggest one-year increase ever recorded – tracking began in 1960
Overall U.S. health spending in 2009 will hit $2.5 trillion, continuing a trend in recent decades that has seen healthcare encompass an ever-larger proportion of the economy.
It is projected that the health share of the economy will increase steadily through 2018. By 2018 health spending will be $4.4 trillion and make up 20.3 percent of the overall economy (it is currently $2.5 trillion and consumes 17.6 percent of the economy)
Spending for private health insurance is slowing as more people lose employer-provided coverage. However private health spending growth is expected to jump from 4.2 percent in 2010 to 6.1 percent by 2018
Growth in public health spending this year is projected to hit 7.4 percent, amounting to $1.2 trillion. This is largely because Medicaid assistance for the poor is ballooning. Public health spending will surge as the baby boom generation begins entering the Medicare health insurance program for people over 65
The CMS forecast reflect the stark reality of the US health system. Eng3 is doing everything we can to help people avoid the need to rely on it. Healthy aging is certainly the most cost effective way to go. Fortunately a growing number of people are investing in their health and taking preventative measures.
Dr Hekimi and colleague Jeremy Van Raamsdonk of McGill University studied mutant worms after they had progressively disabled five genes responsible for detoxifying ROS. Their results call into question the theory that oxidative stress causes aging. They found that reducing mitochondrial activity by damaging it with ROS did not reduce the life span of worms, and in one case made the worms live longer. While the authors refer to aging, it appears they studied longevity. The authors do not appear to have answered questions about the worms’ health and performance after they were damaged. This is perhaps the most important component of aging. It would be interesting to know if these damaged worms remained healthy or just lived as long (or longer) than their undamaged counterparts.
Since the mitochondria (the powerhouse of the cell) was damaged in the McGill study, the worms may have been alive but not as healthy as they otherwise would have been. Hopefully further study will investigate this and the possibility that damaging mitochondrial function resulted in lower oxygen metabolism and, as a result, actually decreased the kind of damage that would shorten the worm’s life. You may also be interested in Oxygen Ironey* and Healthy Aging and Anti Aging
Health and vitality during later stages of life is a primary reason for people to use Eng3’s Activated Air. Our focus is on the quality of life – helping people stay active, alert and vital as they age.
The second week in March is Multiple Sclerosis Awareness Week.
According to the National Institute of Health (NIH), it is estimated that between 250,000 and 350,000 people in the US have been diagnosed with MS, with 200 new cases diagnosed each week. This chronic disease is usually diagnosed in young adults (age 20-40), and those with MS have essentially the same life expectancy as those without MS. Due to the debilitating nature of the disease, “the economic, social, and medical costs associated with the disease are significant” (NIH), costing the US billions of dollars each year.
The cause is still unknown but many believe MS is an autoimmune disease, where the body’s own immune system is attacking the myelin around the nerves. Environment, genetics, viruses are all on the table as possible factors or triggers.
Calabrese et al, note “there is significant evidence that the pathogenesis of…multiple sclerosis… may involve the generation of reactive oxygen species (ROS),” and that there is evidence of mitochondria damage in these neurodegenerative disorders.
It may help to explain this with a bit more information. ROS are byproducts of oxygen metabolism and are highly reactive molecules. (Many people are familiar with the term free radicals – which are a type of ROS.) ROS can cause significant cell damage, also called oxidative stress damage. Mitochondria are damaged by ROS and are then unable to perform their functions, including making energy (ATP) for the cells. When the mitochondria become less effective at producing energy, cells may not function properly. [For more specifics on the role of mitochondria, see this blog.]. Eng3′s Activated Air device is specifically designed to improves cell function – it supports the mitochondria to optimize cell energy production and repairs damage caused by oxidative stress.Calabrese, V., et al., 2005, June 15. Oxidative stress, mitochondrial dysfunction and cellular stress response in Friedreich’s ataxia. The Journal of the Neurological Sciences, 233(1), 145-162.
Eng3′s Activated Air devices are not Oxygen Concentrators and they work in very different ways.
Oxygen concentrators increase the percentage of oxygen that you breathe – up to 100%. But breathing in more oxygen does not necessarily mean your cells can use it.
Eng3′s device modifies the air, so that your cells are able to use the oxygen better; but is not changing the amount of oxygen in the air – you still breathe the natural level of oxygen, about 21%. This improved oxygen utilization can be measured by the energy production of the cells and the amount of oxygen that is exhaled unused. Energy goes up and exhaled oxygen goes down.
The reason this is such an important difference is that the metabolism of oxygen by the cells naturally produces free radicals. This is natural and fine, unless there is an accumulation of free radical damage, which is called oxidative stress. Oxidative stress is associated with all chronic disorders and most diseases. When you breathe concentrated oxygen your cells must metabolize more oxygen, creating excessive free radicals and oxidative stress. Since Eng3’s device does not add more oxygen to your body, it does not create oxidative stress. In fact, our device helps reduce and repair oxidative stress damage by actually improving how your cells function.
For more information on how oxygen is essential, yet harmful – please read Eng3′s blogs:
“Oxygen is a relatively small element—number eight on the Periodic Table, for those who remember their high school chemistry. It is also highly reactive and electrically charged. Electrically charged atoms strive to become neutral, to have a particular number of electrons in their outer shells. Each atom of oxygen, with six electrons, needs two more to be complete. That is why it will eagerly combine with any electron-donating atom—hydrogen, for instance—whenever it is given the opportunity.
In the human body, of course, it is given that opportunity on a breath-by-breath basis. Each time a cells burns its oxygen fuel to create energy, it also creates freewheeling oxygen atoms known as oxygen free radicals.
Therein lies the problem. Oxygen is not discriminating about what other molecular structures it might destroy in its quest to become electrically whole. If there are electrons to spare in a protein molecule, or in the fats that make up a cells’ membrane, or even in the DNA that is crucial to the functioning of our cells and our bodies, it will grab them and change them. This constant cellular wear-and-tear due to the ravages of oxygen is so pervasive that it has been given a name: oxidative stress. And like its psychologically based cousin, oxidative stress can wear down a body over time.
Indeed, the biological consequences of this sort of electron scavenging can be found at the root of the normal process of aging. But it also has a part in cancer. Heart disease. Parkinson’s disease. Name the condition, and somewhere down the line, oxygen free radicals are likely to play a role.”
* Excerpt from Lori Oliwenstein’s article “The Oxygen Irony: Oxygen, the life force found in every breath, also is one of the human body’s most destructive invaders.” USC Health Magazine, 2002.
Eng3′s Activated Air device helps repair and prevent damage caused by oxidative stress.
A common misconception about the terms ‘aging’ and ‘anti-aging’ is that they only refer to living longer. Few credible remedies would claim to extend life. In fact any treatment that claims to extend life is immediately suspect. Far more realistic is the goal of positively influencing quality of life as people age. It seems ‘healthy-aging’ is a more fitting goal than ‘anti-aging’.
The average person’s life span has been getting longer – it has increased by decades during the last century. This is largely the result of reducing infant mortality and infectious diseases. Through science, it has also been possible to reduce early death due to heart problems and other conditions. Increasing life span, however, does not insure or even promote quality of life in later years. In fact, there are more older ill people than ever before. This fact suggests that there may be too much emphases on quantity of life and not enough consideration for quality of life. Statistics appear to confirm this, and it is certainly our experience at Eng3 Corporation. People commonly turn to Eng3’s Activated Air because they already suffer from one or more chronic disease. Our goal is to help people enjoy health and vitality for as long as they live and we are thrilled to see the growing number of people using Eng3’s Activated Air to maintain health and improve performance. Whether Activated Air is used for prevention or to recover form health problems, healthy aging is the key. See also The Growing Impact of Chronic Disease.
Healthy Aging featured an article in their e-newsletter by Kent Holterof, MD called “A Confounding Condition.” The article looks at the troubles with diagnosis and treatment, stating, “When it comes to treating patients with chronic fatigue syndrome (CFS) and fibromyalgia (FM), doctors are often at a loss.”
Holterof writes “Physicians need to employ a multi-system approach, instead of resorting to single-drug modalities for each symptom. This comprehensive approach is largely becoming the standard of care and is effective in 80 percent of patients with these conditions.”
His recommendations for a multi-system approach include 1) Stabilizing the patient; 2) Mitochondrial enhancement; 3) Balance the hormones; 4) Treat the infectious components; 5) Address unique etiologies; and 6) Maintenance.
Lets take closer look at component 2 – Mitochondrial enhancement.
Mitochondria within the cells produce energy (ATP).
Holterof states, “When the mitochondria are not working properly, the cells and tissues of the body are starved for energy. This abnormality may be the common endpoint for all the dysfunctions in CFS and FM.
Not only do the reduced amounts of metabolized glucose produce weight gain, reduced aerobic energy production requires the body to rely on anaerobic metabolism. This causes fatigue, muscle pain, poor concentration, gastrointestinal dysfunction, headaches and postexertional malaise.
….Mitochondria dysfunction has the greatest impact on the most active tissues, including the hypothalamus, pituitary, muscle, nerve and immune cells. These are the major dysfunctions of these conditions and can significantly explain the symptoms of CFS/FM.”
This relates to Eng3 because our technology specifically improves cell function, including mitochondria function to optimize cell energy production. Meaning, breathing Activated Air helps the mitochondria work properly.
Many people take supplements in an effort to support their health and nutrition, but putting nutrients into your body by no means ensures that they are absorbed and used. Elaborate supplementation can produce expensive urine but, unless the nutrients are properly absorbed, supplements will do little to enhance your health, nutrition, or to protect your system.
Proper utilization of nutrients is, of course, a protein function. As a result, Activated Air’s unique ability to support protein function ultimately improves the uptake of nutrients, both in the food we eat and supplements. Antioxidants are a common supplement and important nutrient. Because they help neutralize free radicals, they can help prevent damage caused by oxidative stress. However, antioxidants cannot repair oxidative stress damage. Proteins do this work. By breathing Activated Air, you are improving protein function, which both prevents and repairs free radical/oxidative stress damage.
Last month researchers at Vanderbilt University’s School of Medicine presented interesting results on fibromyalgia and oxidative stress. (1)
Because, as they put it, “Oxidative stress is thought to play a role in the pathogenesis of fibromyalgia” they investigated whether oxidative stress was higher in patients with fibromyalgia and if it was related to the severity of symptoms.
After evaluating 48 control patients with fibromyalgia and comparing them to 96 control subjects, they learned that the results were not entirely as expected. Oxidative stress was associated with fatigue, which is consistent with an earlier study on systemic lupus erythematosus. Additionally, fibromyalgia patients with significantly more fatigue had much higher levels of the oxidative stress marker. Other symptoms of fibromyalgia, however, were not correlated with the oxidative stress marker in this study.
Eng3′s Activated Air device is often used by people with fibromyalgia. Since better sleep is directly related to fatigue, it is not surprising that users are excited about Activated Air. As one enthusiastic customer puts it: “I have fibromyalgia and don’t have nearly the muscle pain I used to since using Activated Air. I am also sleeping better and am less tired.”
~Rose K., Ohio.
(1) “Oxidative stress in fibromyalgia and its relationship to symptoms.” Clinical Rheumatology, Chung CP et. al. December 17, 2008.
With all the great things that activated air can do for your body and your health, we are often asked if there are any negative side effects or contraindications.
Activated air does not contain any chemicals or drugs so it cannot conflict with medications. Because activated air helps improve cell metabolism and oxygen utilization, which means your cells will work better, it supports detoxification. People who are highly sensitive or highly toxic may experience a headache, feeling tired, or even diarrhea. People often report feeling more alert and some new users have trouble sleeping if they use the device too late at night. Once a person is accustomed to activated air, it can be used in the evening without interrupting sleep.
The safest thing is to start slowly when using the activated air device. Start out with 5 minutes and work up to a session of 20 minutes on the large device, or 40 minutes on the small one. Also, the more compromised your health is, the more gentle you should be- increasing the time even more gradually. But, as long as you feel okay, keep increasing the time until you get to a full session and longer. You can’t overuse the device once you have worked up to it, but you don’t want to feel uncomfortable by going too quickly.
Now that the holidays are over, many of us are feeling the effects of all the parties, family gatherings, work parties, and celebrating that come with the holiday season. Along with the increase in social activities there may be an increase in food and alcohol consumption. It is easy for people overindulge this time of year. Unfortunately, the effects of drinking too much alcohol are not only felt the next morning, or seen in the waistline, but may go much deeper, affecting our health and our body’s ability to manage oxidative stress.
An article by Wu and Cederbaum states “Alcohol promotes the generation of ROS and/or interferes with the body’s normal defense mechanisms against these compounds through numerous processes, particularly in the liver.” Alcohol impacts agents such as antioxidants that typically eliminate free radicals, and also can facilitate an increase in free radical production by altering the levels of certain metals in the body. So, alcohol contributes to the production of free radicals, which can result in oxidative stress. Too much oxidative stress can do damage to our bodies and is related to a host of diseases and disorders.
Regardless of the source of oxidative stress, Eng3′s Activated Air device is used to reduce its damage and improve cell metabolism. Because of this, it helps your body combat the ill effects of alcohol.
An interesting study was reprinted in the Archives of Internal Medicine called “Low Heart Rate Variability and the Effect of Depression on Post-Myocardial Infarction Mortality.” The study looked at 311 depressed patients and 367 non depressed patients who had experienced a recent acute Myocardial Infarction (Heart Attack) within the previous 28 days. It presents research “suggesting that low HRV may be a mechanism linking depression to an increased risk for mortality” (p. 1486).
The research notes that low Heart Rate Variability (HRV) is a strong predictor of mortality in patients with a recent heart attack, independent of depression. And that depressed patients have been found to have lower HRV than when compared to medically similar, non depressed patients with stable coronary disease. The study found that a decreased survival rate and low HRV was associated with depression, and that “the effect of depression on survival is partially mediated by low HRV” (p. 1489) and supports that depression is a risk factor in mortality after a heart attack.
“It also raises the possibility that treatments that improve both depression and HRV might also improve survival in these patients” (p. 1486).
Activated Air has been shown to increase HRV, as described in the study by Kuchera available on our research page.
Source: Carney, R., et al. (2005), Low Heart Rate Variability and the Effect of Depression on Post-Myocardial Infaction Mortality. Archives of Internal Medicine, 165, 1486-1491.
In the area of sports and fitness, three areas are positively affected by Activated Air.
1) The intrinsic combustion in the mitochondria, the power plants of the cells, functions better. This results in increased energy production (ATP production).
2) The immune system is strengthened, as each cell produces an increased amount of its own protective enzymes, which neutralize aggressive free radicals. Oxidative stress is mainly responsible for a weak immune system, as the enormous consumption of oxygen automatically and physiologically produces a great number of free radicals.
3) The autonomic nervous system functions verifiable better as the main control and distribution center of all processes in the body after using Activated Air for 20 minutes. This means that internal and external stimuli of the autonomic nervous system are processed faster, more effectively and with fewer errors.
The Activated Air device can be a great help to athletes because it supports all sports and fitness activities. It permits more rigorous training, improves energy levels and most importantly it helps protect the athlete’s health from the damage of oxidative stress.
We have had this question raised in the past few months: Is Activated Air (Eng3 Technology) the same as ozone and ozone therapies?
Since we are not experts on ozone and ozone therapies we cannot make much comment on whether they are beneficial or not. But it is clear that there is great debate across medical communities, alternative medicine communities, and in general on the internet, on the use, benefits, and detriments of ozone on humans. (more…)
According to the American Diabetes Association: “There are 23.6 million children and adults in the United States, or 7.8% of the population, who have diabetes. While an estimated 17.9 million have been diagnosed with diabetes, unfortunately, 5.7 million people (or nearly one quarter) are unaware that they have the disease.” (more…)
Oxidative stress damage is implicated in all chronic diseases which are the most prevalent and costly health care problems in the United States. Nearly half (45%) of all Americans suffer from at least one chronic disease. More than two-thirds of all deaths are caused by one or more of five chronic diseases: heart disease, cancer, stroke, chronic obstructive pulmonary disease, and diabetes. Many chronic diseases (more…)
A study conducted at the University of Texas Medical Branch at Galveston identified a key enzyme found in pollen produced by 39 plant pollens and molds linked to allergies and asthma attacks. When this enzyme came in contact with cells, it was found to create oxidative stress, which then “almost immediately prompted the production of inflammatory immune signaling molecules and accumulation of inflammatory cells, a downstream event common to lung and other type of allergic inflammations” (Kelly, 2005). (more…)
Several years ago Kelvin Davies of the Department of Biochemistry & Molecular Biology, Albany Medical College, wrote an article entitled Oxidative stress: the paradox of aerobic life. This is an excellent discussion of oxidative stress and response. According to Davies, “The paradox of aerobic life, or the ‘Oxygen Paradox’, is that higher eukaryotic aerobic organisms cannot exist without oxygen, yet oxygen is inherently dangerous to their existence.” (more…)
Of course activated air is great for humans, but it is also very beneficial for our four legged friends. We have several owners who use the device with their pets. (more…)
For the last decade studies have been showing a relationship between Chronic Fatigue Syndrome (CFS) and Oxidative Stress. An Australian research team analyzed markers for oxidative stress found in the blood. (more…)
Author Susan Smith Jones, one of ten “Healthy American Fitness Leaders” and renowned author in the fields of optimal health, fitness, anti-aging and nutritional medicine, wrote about Activated Air in her new book: Be Healthy, Stay Balanced (2008, DeVorss Publications).
Susan is a huge proponent of rhythmic and diaphragmatic breathing to improve your quality of life. She notes, “But even the best diaphragmatic breathing cannot stop the cellular aging process. As you age your cells become less able to use the oxygen in the air to generate cell energy. My advice is to optimize your breathing an enhance the air you breathe with Activated Air by Eng3. This natural solution makes oxygen more available to your cells for better mental and physical performance, healthy aging, and for repairing the damage of excessive free radicals.” (p. 105) (more…)
Runners World Magazine, July 2008, contained an article in the Mind + Body section, called Natural Cures: Can alternative remedies offer runners a better route to pain relief? It’s no secret that while running can be great for fitness, it can also be very hard on the body, especially while training for high mileage events such as marathons and half marathons. Sore muscles and fatigue are part of training, but they don’t have to take you out of the game.
Runners World looked at a list of options including Acupuncture, Sports Medicine, Imagery, Herbal Remedies, and Chiropractic Treatment as methods to incorporate into training to help keep runners on the road to their next event, and to recover after crossing the finish line.
We think Eng3′s Activated Air technology should be on that list too. (more…)
World Azheimer’s Day, held September 21, 2008, draws attention to the 26 million people in the world are living with Alzheimer’s, including more than 5 million in the United States. According to the Alzheimer’s Association, researchers predict that by 2050 the global prevalence of the disease will quadruple, affecting more than 100 million individuals. This is a staggering growth rate and there is growing interest in what can be done to stay healthy and avoid being included in these numbers. (more…)
Heart rate variability (HRV) is a measure of the variation in heart rate, depicted by its beat-to-beat spacing. It is used to assess the health of the Autonomic Nervous System (ANS). The ANS is a regulatory structure that helps us adapt to changes in our environment, it controls many muscles and organs, such as the heart, stomach and intestines. Chronic diseases increase stress on the organism and cause a decrease (more…)
Sleep Apnea (or Sleep Apnoea), a condition where people stop breathing for periods of 10 seconds or longer while sleeping, affects up to 18 million people in the US. Interference in breathing reduces the amount of oxygen in the blood. Eventually this lack of oxygen triggers the lungs to suck in air, causing gasping or snorting, and for the person to move to a lighter stage of sleep, or sometimes to wake up. (more…)
We are often asked about the differences between Activated Air and CPAP machines, so we thought we would post the answer here for others who have the same question.
In short, CPAP and Activated Air are very very different. CPAP (Continuous Positive Airway Pressure) works by providing a stream of compressed air (usually through a mask) to keep the airway open under pressure, (more…)
National Cancer Survivors Day is on Sunday, June 8th this year. Celebrations are held the first Sunday in June in communities around the world, to honor those who have survived cancer. “It is a symbolic event to demonstrate that life after cancer diagnosis can be a reality” states the official website for National Cancer Survivors Day. (more…)
Eng3 has been invited to display our device in the booth of Donna Gates at the International Association for Colon Hydrotherapy (I-ACT). Donna is speaking at I-ACT about “Tools to Nurture Yourself While Educating Your Clients to Digestive Wellness”. Her talk promises to be insightful and Eng3 is honored to be included and associated with this highly acclaimed author who devised the Body Ecology Diet. (more…)
Healthy aging, which is often what people mean when they say “anti-aging”, is a popular preoccupation. When a person is in their 30s, their cell’s ability to metabolize oxygen starts to decline. They may notice lower energy levels in their 40s and by the time they are in their 50s, most people are interested in ways to improve their health and vitality. Healthy aging becomes a high priority and this requires improving oxygen utilization. (more…)
According to Health, United States 2005, 65% of Americans above the age of 19 are overweight. Because weight is so important to health, we have a fair number of inquires about it. Eng3’s device supports the weight loss process by helping cell metabolism, most importantly oxygen metabolism. Leading author Dr. Susan Smith Jones explains it this way while discussing Eng3 in her recent book: (more…)
We have received many calls since a posting at the Trigeminal Neuralgia Association (TNA) site earlier this year. Because of the nature of this condition, which is widely considered the most painful disorder known to medicine, we have a keen interest in it. Eng3 does not have formal studies to share with you but we are happy to answer your questions and provide references. (more…)
